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The search for the mouse X-chromosome inactivation centre

Published online by Cambridge University Press:  14 April 2009

S. Rastan  and
S. D. M. Brown
S. Rastan*
Affiliation:
Section of Comparative Biology, Clinical Research Centre, Harrow, Middlesex HA1 3UJ, UK
S. D. M. Brown
Affiliation:
Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, London W2 1PG, UK
*
‡ Corresponding author.

Summary

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The phenomenon of X-chromosome inactivation in female mammals, whereby one of the two X chromosome present in each cell of the female embryo is inactivated early in development, was first described by Mary Lyon in 1961. Nearly 30 years later, the mechanism of X-chromosome inactivation remains unknown. Strong evidence has accumulated over the years, however, for the involvement of a major switch or inactivation centre on the mouse X chromosome. Identification of the inactivation centre at the molecular level would be an important step in understanding the mechanism of X-inactivation. In this paper we review the evidence for the existence and location of the X-inactivation centre on the mouse X-chromosome, present data on the molecular genetic mapping of this region, and describe ongoing strategies we are using to attempt to identify the inactivation centre at the molecular level.

Type
Research Article
Information
Genetics Research , Volume 56 , Issue 2-3 , October 1990 , pp. 99 - 106
Copyright
Copyright © Cambridge University Press 1990

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