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Genetic analysis of a new haplotype of the histidine decarboxylase gene complex in C57BL/6 mice

Published online by Cambridge University Press:  14 April 2009

S. A. M. Martin  and
Crahame Bulfield
S. A. M. Martin
Affiliation:
Department of Genetics, Edinburgh University, West Mains Road, Edinburgh EH9 3JN, U.K.
Crahame Bulfield
Affiliation:
Genetics Group, AFRC Poultry Research Centre, Roslin, Midlothian EH25 9PS, U.K.

Summary

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The histidine decarboxylase (HDC) gene complex, [Hdc], comprises the structural gene for mouse kidney HDC and closely linked regulatory elements which determine enzyme concentration and its response to hormones. One of these regulatory elements, Hdc-e, determines the response (induction or repression) of kidney HDC to oestrogen. HDC is oestrogen-inducible in C57BL/10 and oestrogen-repressible in DBA/2 and C57BL/6; alleles of Hdc-e segregate in crosses between C57BL/10 and DBA/2 and between the C57BL substrains. Two different haplotypes of[Hdc] have been defined previously, B.10 (Hdc-sb, Hdc-cb, Hdc-eb) in C57BL/10 and D (Hdc-sa, Hdc-cd, Hdc-ed) in DBA/2. C57BL/6 represents a third haplotype (B.6) (Hdc-sb, Hdc-cb, Hdc-ed) which differs from both B.10 and D. Hdc-e may therefore be a component of the complex independent of Hdc-s and Hdc-c.

Type
Research Article
Information
Genetics Research , Volume 47 , Issue 2 , April 1986 , pp. 131 - 134
Copyright
Copyright © Cambridge University Press 1986

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