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A gene (Neu-1) on chromosome 17 of the mouse affects acid α-glucosidase and codes for neuraminidase
Published online by Cambridge University Press: 14 April 2009
An electrophoretically detectable variant of acid α-glucosidase has been found in SM/J mice. This variant is attributable to excess sialylation of the enzyme and is determined by a gene, alpha-glucosidase processing, Aglp, on chromosome 17. In addition, as also reported by Potier, Lu Shun Yan & Womack (1979), SM/J mice are relatively deficient in neuraminidase and it appears that the low level of this enzyme in SM/J is determined by an autosomal codominant gene, neuraminidase-1, Neu-1. Preliminary data indicate that Neu-1 is also on chromosome 17. It seems probable that the several processing genes Apl, Aglp and Map-2 which are all closely linked on chromosome 17 are one and the same, a gene Neu-1 coding for neuraminidase.
- Research Article
- Genetics Research , Volume 38 , Issue 1 , August 1981 , pp. 47 - 55
- Copyright © Cambridge University Press 1981