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Controlling elements in the mouse X-chromosome: I. Interaction with the X-linked genes

Published online by Cambridge University Press:  14 April 2009

B. M. Cattanach
Affiliation:
City of Hope Medical Center, Duarte, California, U.S.A.
C. E. Pollard
Affiliation:
City of Hope Medical Center, Duarte, California, U.S.A.
J. N. Perez
Affiliation:
City of Hope Medical Center, Duarte, California, U.S.A.

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The mouse X-chromosome controlling elements, detected by their influence on the position effect variegation caused by the X-autosome translocation T (1; X) Ct, have been found to modify the heterozygous phenotypes of two X-linked genes. It is proposed that X-inactivation can be incomplete, the level of inactivation or the frequency of cells in which inactivation is incomplete being dependent upon the ‘state’ of the controlling element located in the X. The data suggest that this is a consequence of a reversal, or partial reversal, of inactivation of the X as a whole in some cells rather than a vairable spread of inactivation along the length of the X.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1969

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