Hostname: page-component-7c8c6479df-27gpq Total loading time: 0 Render date: 2024-03-28T09:12:53.243Z Has data issue: false hasContentIssue false

Thought disorder: a left lateralised breakdown of the language network

Published online by Cambridge University Press:  16 April 2020

H. Horn
Affiliation:
University Hospital of Psychiatry Bern, Bern, Switzerland
K. Jann
Affiliation:
University Hospital of Psychiatry Bern, Bern, Switzerland
S. Walther
Affiliation:
University Hospital of Psychiatry Bern, Bern, Switzerland
A. Federspiel
Affiliation:
University Hospital of Psychiatry Bern, Bern, Switzerland
M. Wirth
Affiliation:
University Hospital of Psychiatry Bern, Bern, Switzerland
T. Müller
Affiliation:
University Hospital of Psychiatry Bern, Bern, Switzerland
W. Strik
Affiliation:
University Hospital of Psychiatry Bern, Bern, Switzerland

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction

Structural and functional deviations in schizophrenic patients with formal thought disorder (FTD) point towards a dysfunction within left sided language network.

Objectives

Independent component analysis (ICA), a new approach to fMRI analysis, enables to target the question of a network dysfunction directly. Using this method in healthy controls it was possible to identify the language networks separately for the left and the right hemispheres In the present study we use ICA analysis to examine changes of the language network separate for each hemisphere in relation to the severity of FTD.

Aims

We hypothesize increasing disintegration with increasing severity of FTD only in the left sided language network while the right language network should remain unaffected.

Methods

We investigated 16 schizophrenic patients with different severity of FTD and matched healthy controls using ICA decomposition of the BOLD signal. The spatial similarity of the individual language networks was correlated to the severity of FTD.

Results

The integrity of the left language network decrease with increasing severity of FTD (r = -0.79, p < 0.01), while the integrity of the right language network show no significant correlation to the severity of FTD.

Conclusion

For the first time the isolated breakdown of the left sided language network was linked specifically to schizophrenic FTD. This result unites older manly left hemispheric findings of structural and functional abnormalities in schizophrenic FTD.

Type
P03-231
Copyright
Copyright © European Psychiatric Association 2011
Submit a response

Comments

No Comments have been published for this article.