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Substance Use and Early Psychosis Course

Published online by Cambridge University Press:  15 April 2020

I. Tarricone ,
J. Boydell ,
C. Morgan ,
M. Robin ,
M. Di Forti  and
D. Berardi
I. Tarricone
Affiliation:
Bologna University, Department of Medical and Surgical Science, Bologna, Italy
J. Boydell
Affiliation:
King's College London, Psychosis Studies, London, United Kingdom
C. Morgan
Affiliation:
King's College London, Health Services and Population research, London, United Kingdom
M. Robin
Affiliation:
King's College London, Psychosis Studies, London, United Kingdom
M. Di Forti
Affiliation:
King's College London, Psychosis Studies, London, United Kingdom
D. Berardi
Affiliation:
Bologna University, Department of Medical and Surgical Science, Bologna, Italy

Abstract

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Objectives

Substance abuse is a well established risk factor for First-Episode Psychosis (FEP). We hypothesized that substance use at baseline could be an independent risk factorfor a worse clinical course.

Methods

An incidence cohort ofpatients with FEP collected in an 8 year period (2002-2009) at the Bologna WestCommunity Mental Health Centers (CMHCs) was assessed at baseline and at 12 month follow-up. Hospitalizations were used as clinical outcomes.

Results

Substance users had asignificantly higher rate of hospitalizations during the follow-up after adjusting for age, gender and other potential confounders (OR 5.84, 95% CI 2.44-13.97, p≤0.001).

Conclusions

This study showed the independent effect of substance use on FEP course. Clinical implications will be discussed.

Tarricone I, Boydell J, Panigada S, Allegri F, Marcacci T, Minenna MG, Kokona A, Triolo F, Storbini V, Michetti R, Morgan C, Di Forti M, Murray RM, Berardi D. The impact of substance use at psychosis onset on First Episode Psychosis course: results from a 1 year follow-up study in Bologna. Schizophr Res. 2014 153(1-3):60-3.

Allegri F, Belvederi Murri M, Paparelli A, Marcacci T, Braca M, Menchetti M, Michetti R, Berardi D, Tarricone I. Current cannabis use and age of psychosis onset: a gender-mediated relationship? Results from an 8-year FEP incidence study in Bologna. Psychiatry Res. 2013 Nov 30;210(1):368-70.

Type
Article: 1762
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015

References

Tarricone, IBoydell, JPanigada, SAllegri, FMarcacci, TMinenna, MGKokona, ATriolo, FStorbini, VMichetti, RMorgan, CDi Forti, MMurray, RMBerardi, DThe impact of substance use at psychosis onset on First Episode Psychosis course: results from a 1 year follow-up study in Bologna. Schizophr Res 153 (1–3) 2014 60–6310.1016/j.schres.2014.01.014CrossRefGoogle ScholarPubMed
Allegri, FBelvederi Murri, MPaparelli, AMarcacci, TBraca, MMenchetti, MMichetti, RBerardi, DTarricone, ICurrent cannabis use and age of psychosis onset: a gender-mediated relationship? Results from an 8-year FEP incidence study in Bologna. Psychiatry Res 2013 Nov 30; 210(1): 368–37010.1016/j.psychres.2013.06.010CrossRefGoogle ScholarPubMed
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