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Spanih Validation of TOOL Questionnaire: A New Instrument to Assess Quality of Life in Patients with Schizophrenia and Bipolar Disorder

Published online by Cambridge University Press:  16 April 2020

A. Montejo
Affiliation:
Department of Psychiatry, University of Salamanca, Salamanca, Spain
J. Correas Lauffer
Affiliation:
Department of Psychiatry, Hospital de Henares, Madrid, Spain
F. Porras
Affiliation:
CSM Nou Barris, Barcelona, Spain
T. Martin
Affiliation:
CSM Parla, Madrid, Spain
P. Ruiz Carrasco
Affiliation:
CSM Ntra Sra del Aguila, Sevilla, Spain
L. Cordero
Affiliation:
AstraZeneca Medical Department, Madrid, Spain
T. Diez
Affiliation:
AstraZeneca Medical Department, Madrid, Spain
J. Maurino
Affiliation:
AstraZeneca Medical Department, Madrid, Spain

Abstract

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Objective:

Develop a cross-cultural translation, Swedish to Spanish, of TOOL questionnaire - a previously validated instrument to assess the impact of adverse effects (AE) on the health utilities and health related quality of life (HRQoL) in patients with schizophrenia and bipolar disorder.

Methods:

TOOL questionnaire has 8 attributes and 4 levels per domain: mood (anxiety and depression), function capabilities, and AE frequently associated with antipsychotics (fatigue-weakness, weight gain, stiffness-tremor, physical restlessness, sexual dysfunction, and vertigo-nausea). Firstly, 4 independent translators carried out the forward-backward translations. Next, draft version was reviewed by an experts panel (5 psychiatrists & 1 GP specialized in HRQoL) and tested in 40 stable patients (20 schizophrenic & 20 bipolar). Comprehension and importance (C/I) of each item were evaluated by a Likert scale ranging from 0 (lowest level) to 4 (highest level).

Results:

3 items should be modified to facilitate comprehension: mood, physical restlessness and vertigo-nausea. However, C/I of items mean scores were respectively: mood (3.50/ 2.37); function capabilities (2.58/ 2.03); fatigue-weakness (3.58/ 2.55); weight gain- (3.75/ 2.87); stiffness-tremor (3.65/ 2.61); restlessness (3.37/ 2.62); sexual dysfunction (3.39/ 2.51) and vertigo-nausea (3.56/ 2.44). Only 2 patients (5%) were unable to complete the questionnaire. Internal consistency was high (Cronbach α= 0.87) and neither item ceiling nor floor effects were found.

Conclusions:

The Swedish TOOL questionaire was culturally adapted into Spanish. Psychometric analyses are needed to validate this measure in Spain. A multtiatribute utility fuction should be estimated to evaluate AE by using a patients"centered perspective.

Type
P02-257
Copyright
Copyright © European Psychiatric Association 2009
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