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Social functioning and cognition in patients with schizophrenia, their unaffected siblings and healthy controls: impact on quality of life

Published online by Cambridge University Press:  16 April 2020

D.D. Achaval
Affiliation:
CONICET, Buenos Aires, Argentina
K. Buglioni
Affiliation:
Cognitive Neurology, Buenos Aires, Argentina
J. Lopez
Affiliation:
Cognitive Neurology, Buenos Aires, Argentina
J. Douer
Affiliation:
Cognitive Neurology, Buenos Aires, Argentina
E. Costanzo
Affiliation:
Psychiatry, Buenos Aires, Argentina
M. Mora
Affiliation:
Agencia de Promocion Cientifica MINCyT, FLENI - Cognitive Neurology & Neuropsychiatry, Buenos Aires, Argentina
R. Fahrer
Affiliation:
Psychiatry, Buenos Aires, Argentina
S. Guinjoan
Affiliation:
CONICET, Buenos Aires, Argentina

Abstract

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Background

Patients with schizophrenia show deficits in many cognitive domains and social functioning, social skills, and self management skills in their daily life activities.

Objective

To evaluate the relationship between general-social cognition, mental state and social functioning, and impact on quality of life.

Methods

Twenty patients with chronic disorder of schizophrenia were evaluated and compared with 20 siblings and 20 healthy controls regarding performance in a series of tests: Cognitive Screening: Word Accentuation Test, MCCB (Matrics Consensus Cognitive Battery) Social Functioning: UPSA (University of California Performance Skills Assessment), TABS (Test of Adaptive Behaviour in Schizophrenia), SSPA (Social Skills Performance Assessment), Beck and Hamilton depression scales, Scale for Positive and Negative Syndrome of Schizophrenia, and SF-36 as indicator of quality of life.

Results

Patients showed significant differences from controls and siblings in MCCB total score (p < 0.001), whereas siblings showed significant differences compared to controls in MCCB total score (p = 0.053). Siblings performed differently from patients (p < 0.001) and controls (p = 0.019) in social functioning measured with TABS. A series of correlations between general cognition and social functioning were demonstrated for patients and their unaffected siblings (not shown).

Conclusion

Results suggest that the performance of nonpsychotic siblings is located between patients and healthy controls, suggesting that social performance measures are (or associated with) intermediate phenotypes of the disease. General and social cognition have a complex relationship with social functioning and quality of life.

Type
P03-229
Copyright
Copyright © European Psychiatric Association 2011
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