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Skunk and psychosis in South East London

Published online by Cambridge University Press:  16 April 2020

M. Di Forti
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
C. Morgan
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
V. Mondelli
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
L. Gittens
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
R. Handley
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
N. Hepgul
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
S. Luzi
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
T. Marques
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
M. Aas
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
S. Masson
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
C. Prescott
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
M. Russo
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
P. Sood
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
B. Wiffen
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
P. Papili
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
P. Dazzan
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
C. Pariante
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
K. Aitchison
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
J. Powell
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK
R. Murray
Affiliation:
Institute of Psychiatry, Division of Psychological Medicine, King's College London, London, UK

Abstract

Background:

Epidemiological studies have reported that the increased risk of developing psychosis in cannabis users is dose related. In addition, experimental research has shown that the active constituent of cannabis responsible for its psychotogenic effect is Delta-9-Tetrahydrocannabinol (THC) (Murray et al, 2007). Recent evidence has suggested an increased in potency (% TCH) in the cannabis seized in the UK (Potter et al, 2007).

Hypothesis:

We predicted that first episode psychosis patients are more likely to use higher potency cannabis and more frequently than controls.

Methods:

We collected information concerning socio-demographic, clinical characteristics and cannabis use (age at first use, frequency, length of use, type of cannabis used) from a sample of 191 first-episode psychosis patients and 120 matched healthy volunteers. All were recruited as part of the Genetic and Psychosis (GAP) study which studied all patients who presented to the South London and Maudsley Trust.

Results:

There was no significant difference in the life-time prevalence of cannabis use or age at first use between cases and controls. However, cases were more likely to be regular users (p=0.05), to be current users (p=0.04) and to have smoked cannabis for longer (p=0.01). Among cannabis users, 86.8% of 1st Episode Psychosis Patients preferentially used Skunk/Sinsemilla compared to 27.7% of Controls. Only 13.2 % of 1st Episode psychosis Patients chose to use Resin/Hash compared to 76.3% of controls. The concentration of TCH in these in South East London, ranges between 8.5 and 14 % (Potter et al, 2007). Controls (47%) were more likely to use Hash (Resin) whose average TCH concentration is 3.4% (Potter et al, 2007).

Conclusions:

Patients with first episode psychosis have smoked higher potency cannabis, for longer and with greater frequency, than healthy controls.

Type
S06-04
Copyright
Copyright © European Psychiatric Association 2009
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