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Remission in the outpatient care of schizophrenia: 3-Year results from the Schizophrenia Outpatients Health Outcomes (SOHO) Study in France

Published online by Cambridge University Press:  24 June 2008

Isabelle Gasquet ,
Josep Maria Haro ,
Stéphanie Tcherny-Lessenot ,
Florence Chartier  and
Jean-Pierre Lépine
Isabelle Gasquet*
Affiliation:
National Institute of Health and Medical Research-U669, Maison de Solenn, Cochin Hospital, Paris, France Direction de la Politique Médicale, Assistance Publique-Hôpitaux de Paris, Paris, France
Josep Maria Haro
Affiliation:
Research & Development Unit, San Joan de Deu-SSM, Sant Boi, Barcelona, Spain
Stéphanie Tcherny-Lessenot
Affiliation:
Pharmacoepidemiology Unit, Lilly France, Suresnes, France
Florence Chartier
Affiliation:
Pharmacoepidemiology Unit, Lilly France, Suresnes, France
Jean-Pierre Lépine
Affiliation:
Psychiatry Department, Fernand Widal Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
*
*Corresponding author. Address: INSERM U669, AP-HP Hôpital Cochin, Maison de Solenn, 97 Boulevard Port-Royal, 75679 Paris, France. E-mail address: isabelle.gasquet@sap.aphp.fr (I. Gasquet).
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Abstract

Objective

To analyse the contribution of socio-demographics, clinical profile and psychotropic treatment on remission in patients with schizophrenia.

Methods

Among 933 French outpatients recruited in the European observational Schizophrenia Outpatient Health Outcomes study (SOHO), 563 were followed-up for 3 years, had at most one missing visit, and were included in the analysis. Symptomatic remission was defined as a score of 3 (mild severity) or less on the Clinical Global Impression-Schizophrenia (CGI) overall, positive, negative and cognitive symptom scales, maintained for at least 6 months and without hospitalization. A logistic regression model was used to analyse the factors associated with time in remission.

Results

60.6% of patients achieved remission during the 3-year follow-up. Patients never treated before inclusion in the study (OR = 2.3) and those having paid employment (OR = 1.4) were more likely to achieve remission. Higher baseline clinical severity was associated with a significantly lower likelihood of achieving remission: CGI overall (OR = 0.67), CGI positive (OR = 0.85) and CGI negative (OR = 0.74). Compared with olanzapine, other atypicals (OR = 0.71) and conventional antipsychotics (OR = 0.69) were associated with a lower probability of achieving remission.

Conclusions

Remission can be achieved in a high proportion of patients. Factors such as being previously untreated, having paid employment and taking olanzapine are predictors of remission.

Keywords

SchizophreniaRemissionAntipsychotic agents
Type
Original article
Information
European Psychiatry , Volume 23 , Issue 7 , October 2008 , pp. 491 - 496
Copyright
Copyright © Elsevier Masson SAS 2008

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