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Relationships between neurocognition, social cognition and functional outcome in schizophrenia

Published online by Cambridge University Press:  23 March 2020

A. Mucci ,
S. Galderisi ,
A. Rossi ,
P. Rocca ,
A. Bertolino ,
P. Bucci  and
M. Maj
A. Mucci*
Affiliation:
University of Naples SUN, Department of Psychiatry, Naples, Italy
S. Galderisi
Affiliation:
University of Naples SUN, Department of Psychiatry, Naples, Italy
A. Rossi
Affiliation:
University of L’Aquila, Department of Biotechnological and Applied Clinical Sciences Section of Psychiatry, L’Aquila, Italy
P. Rocca
Affiliation:
University of Turin, Department of Neuroscience Section of Psychiatry, Turin, Italy
A. Bertolino
Affiliation:
University of Bari, Department of Neurological and Psychiatric Sciences, Bari, Italy
P. Bucci
Affiliation:
University of Naples SUN, Department of Psychiatry, Naples, Italy
M. Maj
Affiliation:
University of Naples SUN, Department of Psychiatry, Naples, Italy
*
* Corresponding author.

Abstract

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Introduction

The inter-relationships of neurocognition, social cognition, residual psychopathology and real-life functioning are poorly understood. A large multicenter study was carried out by the Italian Network for Research on Psychoses to model relationships between neurocognitive deficits, psychopathology and real-life functioning, taking into account the role of functional capacity and social cognition.

Methods

A structural equation model was used to investigate direct and indirect effects of neurocognition and psychopathology on real-life functioning. Social cognition and functional capacity were modeled as mediators.

Results

In 921 patients with schizophrenia, neurocognition had both direct and indirect effects, through functional capacity and social cognition, on real-life functioning. Neurocognition predicted to a large extent social cognition on which depression and disorganization had a modest effect. Social cognition showed a significant direct impact on real-life functioning.

Conclusion

Our results support a strong link between neurocognition and functional outcome, independent of psychopathology. Social cognition accounted for unique incremental variance in real-life functioning.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
W36
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S67
Copyright
Copyright © European Psychiatric Association 2016
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