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Quality of life in patients undergoing opioid maintenance therapy - A comparative study of slow release morphine versus methadone treatment

Published online by Cambridge University Press:  16 April 2020

B. Winklbaur
Affiliation:
Department of Psychiatry, Medical University Vienna, Vienna, Austria
N. Ebner
Affiliation:
Department of Psychiatry, Medical University Vienna, Vienna, Austria
R. Jagsch
Affiliation:
Faculty of Psychology, University of Vienna, Vienna, Austria
K. Thau
Affiliation:
Department of Psychiatry, Medical University Vienna, Vienna, Austria
G. Fischer
Affiliation:
Department of Psychiatry, Medical University Vienna, Vienna, Austria

Abstract

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Background:

Increasing research interest is focussing also on Quality of Life (QoL) in substance dependent individuals. QoL-assessments have been acknowledged as promising measurements in order to evaluate drug treatment programs.

Methods:

A prospective, randomized, double-blind, double-dummy, cross-over study design was used in order to compare methadone and slow-release morphine maintenance on patients´ QoL. Sixty-four participants were randomized between two treatment groups receiving either slow-release morphine capsules for 7 weeks followed by methadone oral solution for another 7 weeks (group A), or vice versa (group B). At baseline, week 7 and week 14 QoL status was evaluated using the German version of the Lancashire Quality of Life Profile.

Results:

A significant time effect with respect to the domains: general state of health (0.018), mental health (p=0.001), general well-being (p<0.001), leisure time at home (p=0.032) and leisure time out of home (p=0.008). Our findings did not show any statistically significant differences between between the two treatment groups in any Quality of Life scores at week 7 and 14. At the end of study phase (week 14) group A showed significant increases in the domains general well-being (0.010), leisure time at home (p=0.014). Significant improvements for group B were assessed with regard to general well-being (p=0.003), mental health (p=0.003) and general state of health (p=0.017).

Conclusions:

The development of treatment programs should focus also on the patients´ subjective perspective. According to our findings agonistic opioid maintenance treatment yields not only to treatment response but also to improvements in patients quality of life.

Type
Poster Session 1: Alcoholism and Other Addictions
Copyright
Copyright © European Psychiatric Association 2007
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