Hostname: page-component-7c8c6479df-hgkh8 Total loading time: 0 Render date: 2024-03-29T15:33:20.541Z Has data issue: false hasContentIssue false

Psychopathological networks in psychosis and changes over time: A long-term cohort study of first-episode psychosis

Published online by Cambridge University Press:  01 September 2022

G. Gil-Berrozpe*
Affiliation:
Instituto de investigación Sanitaria de Navarra (IdiSNA), Psychiatry Unit, Complejo Hospitalario De Navarra, Pamplona, Spain
V. Peralta
Affiliation:
Instituto de investigación Sanitaria de Navarra (IdiSNA), Psychiatry Unit, Complejo Hospitalario De Navarra, Pamplona, Spain
A. Sánchez-Torres
Affiliation:
Instituto de investigación Sanitaria de Navarra (IdiSNA), Psychiatry Unit, Complejo Hospitalario De Navarra, Pamplona, Spain
L. Moreno-Izco
Affiliation:
Instituto de investigación Sanitaria de Navarra (IdiSNA), Psychiatry Unit, Complejo Hospitalario De Navarra, Pamplona, Spain
E. Garcia De Jalon
Affiliation:
Instituto de investigación Sanitaria de Navarra (IdiSNA), Psychiatry Unit, Complejo Hospitalario De Navarra, Pamplona, Spain
D. Peralta
Affiliation:
Instituto de investigación Sanitaria de Navarra (IdiSNA), Psychiatry Unit, Complejo Hospitalario De Navarra, Pamplona, Spain
L. Janda
Affiliation:
Instituto de investigación Sanitaria de Navarra (IdiSNA), Psychiatry Unit, Complejo Hospitalario De Navarra, Pamplona, Spain
M. Cuesta
Affiliation:
Instituto de investigación Sanitaria de Navarra (IdiSNA), Psychiatry Unit, Complejo Hospitalario De Navarra, Pamplona, Spain
*
*Corresponding author.

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction

First-episode psychosis is a critical period for early interventions to reduce the risk of poor outcomes and relapse as much as possible. There are now many studies revealing the patterns of course in the short and medium terms, but uncertainties about the long-term outcomes of symptomatology remain to be ascertained.

Objectives

First, we ascertained whether the structure of psychopathological symptoms, dimensions and domains of psychopathology remains invariant over time between first-episode psychosis and long-term follow-up. Second, we analysed the changes in the interrelationships of psychopathological symptoms, dimensions and domains of psychopathology between FEP and long-term follow-up at three levels.

Methods

We performed network analysis to investigate first-episode and long-term stages of psychosis at three levels of analysis: micro, meso and macro. The sample was a cohort of 510 patients with first-episode psychoses from the SEGPEP study, who were reassessed at the long-term follow-up (n = 243). We used the Comprehensive Assessment of Symptoms and History (CASH) for their assessments.

Results

Our results showed a similar pattern of clustering between first episodes and long-term follow-up in seven psychopathological dimensions at the micro level, 3 and 4 dimensions at the meso level, and one at the macro level. They also revealed significant differences between first-episode and long-term network structure and centrality measures at the three levels.

Conclusions

Our findings suggest that disorganization symptoms have more influence in long-term stabilized patients. The main results of the current study add evidence to the hierarchical, dimensional and longitudinal structuring of first-episode psychoses.

Disclosure

No significant relationships.

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
Submit a response

Comments

No Comments have been published for this article.