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Patient satisfaction with psychotropic drugs: sensitivity to change and relationship to clinical status, quality-of-life, compliance and effectiveness of treatment. Results from a nation-wide 6-month prospective study

Published online by Cambridge University Press:  16 April 2020

Isabelle Gasquet ,
Stéphanie Tcherny-Lessenot ,
Jean-Pierre Lépine  and
Bruno Falissard
Isabelle Gasquet*
Affiliation:
National Institute of Health and Medical Research-U669 (Paris–Sud Innovation Group in Adolescent Mental Health Methodology), Maison des Adolescents, Cochin Hospital, Paris, France Direction de la Politique Médicale, Assistance Publique-Hôpitaux de Paris, Paris, France
Stéphanie Tcherny-Lessenot
Affiliation:
Lilly France, Suresnes, France
Jean-Pierre Lépine
Affiliation:
Psychiatry Department, Fernand Widal Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
Bruno Falissard
Affiliation:
National Institute of Health and Medical Research-U669 (Paris–Sud Innovation Group in Adolescent Mental Health Methodology), Maison des Adolescents, Cochin Hospital, Paris, France
*
*Corresponding author. E-mail address: isabelle.gasquet@sap.aphp.fr (I. Gasquet).
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Abstract

Objective

To see if patient satisfaction with psychotropics (PSP) could be used as a patient-oriented outcome variable in the evaluation of PSP drugs in clinical epidemiological studies, relationships between PSP, clinical status, QoL, compliance and the type of antipsychotic were analyzed. Elements of validation of PSP were also assessed.

Method

In a 6-month prospective study, 933 schizophrenic outpatients with initiation or change to their antipsychotic treatment were enrolled. Psychiatrists completed five CGI-SCH scales (positive, negative, cognitive, depressive and global), hospitalization, compliance, and prescription variables. Patients completed PSP, EuroQoL scales, sexual function and compliance variables.

Results

A satisfactory structural equation model was obtained showing significant relationships PSP/compliance (coef. = 0.16), QoL/PSP (coef. = 0.37), clinical status/QoL (coef. = 0.61), clinical status/compliance (coef. = 0.09). Patients receiving olanzapine were more satisfied than patients receiving other atypicals (coef. =0 12) and had better clinical status than patients treated with typicals (coef. = 0.08). Evolution of PSP was related to clinical status, QoL, and continuation of treatment (all P < 001). Sensitivity to change of PSP was moderate (effect size = 0.2).

Conclusion

PSP produced consistent results in relation to validated outcome variables. However, a single-item measure was not sufficiently sensitive to change. Multi-item questionnaires evaluating different dimensions are needed.

Keywords

Patient satisfactionSchizophreniaPsychometricsQuality-of-lifePatient complianceAntipsychotic agents
Type
Original article
Information
European Psychiatry , Volume 21 , Issue 8 , December 2006 , pp. 531 - 538
Copyright
Copyright © Elsevier Masson SAS 2006

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