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P03-293 - Alcohol And Aldehyde Dehydrogenase Polymorphisms And Risk For Suicide

Published online by Cambridge University Press:  17 April 2020

A. Hishimoto
Affiliation:
Dept. of Psychiatry, Kobe Univ. Graduate School of Medicine, Kobe, Japan
K. Mouri
Affiliation:
Dept. of Psychiatry, Kobe Univ. Graduate School of Medicine, Kobe, Japan
M. Fukutake
Affiliation:
Dept. of Psychiatry, Kobe Univ. Graduate School of Medicine, Kobe, Japan
K. Shiroiwa
Affiliation:
Dept. of Psychiatry, Kobe Univ. Graduate School of Medicine, Kobe, Japan

Abstract

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Excessive alcohol consumption plays a crucial role in the pathogenesis of suicide. Because certain functional alleles of alcohol dehydrogenase (ADH1B) and mitochondrial aldehyde dehydrogenase (ALDH2) genes affect alcohol consumption, we explored associations of the ADH1B and ALDH2 genetic variants with suicide in 317 Japanese males. We found the active ALDH2 allele was significantly more frequent in the completed suicides. Individuals bearing alcoholism-susceptible homozygotes at both loci have 6 times greater risk for suicide. Our data show the genetic impact of the two polymorphisms on suicidal behaviour and presence of the active ALDH2 allele may increase the risk for suicide.

Type
Suicidology and suicide prevention
Copyright
Copyright © European Psychiatric Association 2010
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