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Neutrophin signalling in first-episode psychosis: relationship with treatment response 1 year after the illness onset

Published online by Cambridge University Press:  23 March 2020

M. Martinez-cengotitabengoa ,
K. Macdowell ,
S. Alberich ,
M. Parellada ,
P. Saiz ,
R. Rodriguez ,
E. Berrocoso ,
M. Bernardo ,
A. Gonzalez-pinto  and
J.C. Leza
M. Martinez-cengotitabengoa*
Affiliation:
CIBERSAM-University Hospital of Alava- National Distance Education University UNED, Psychiatry, Vitoria, Spain
K. Macdowell
Affiliation:
CIBERSAM- Universidad Complutense de Madrid, Pharmacology, Madrid, Spain
S. Alberich
Affiliation:
CIBERSAM- University Hospital of Alava, Psychiatry, Vitoria, Spain
M. Parellada
Affiliation:
CIBERSAM- Hospital General Universitario Gregorio Marañon- Universidad Complutense de Madrid, Psychiatry, Madrid, Spain
P. Saiz
Affiliation:
CIBERSAM- Universidad de Oviedo, Psychiatry, Oviedo, Spain
R. Rodriguez
Affiliation:
CIBERSAM- Insituto de Investigacion 12 de Octubre, Psychiatry, Madrid, Spain
E. Berrocoso
Affiliation:
CIBERSAM- Universidad de Cadiz, Pharmacology, Cadiz, Spain
M. Bernardo
Affiliation:
CIBERSAM- Hospital Clinic y Universidad de Barcelona, Psychiatry, Barcelona, Spain
A. Gonzalez-pinto
Affiliation:
CIBERSAM- University Hospital of Alava- University of the Basque Country EHU-UPV, Psychiatry- Neurosciences, Vitoria, Spain
J.C. Leza
Affiliation:
CIBERSAM- Universidad Complutense de Madrid, Pharmacology, Madrid, Spain
*
*Corresponding author.

Abstract

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Introduction

Pro/antiinflammatory imbalance has been found in first-episode psychotic (FEP) patients, even 12 months later. Current research is every time more focused in the need to find biomarkers to understand the underlying pathophysiological mechanisms of this severe illness.

Objectives

To assess peripherical levels of neurotrophins and their receptors and their correlation with inflammation, clinical symptomatology and response to antipsychotic treatment, over the time.

Methodology

Ninety-four FEP patients and 80 matched healthy controls were included. Blood samples were taken at baseline to measure BDNF and NGF and their receptor levels (TrkB-full, TrkB-truncated and TrkA) and pro/antiinflammatory parameters (NFkB, COX-2, iNOS, PPARgamma, 15d-PG12). Patients were followed-up during 12 months.

Results

BDNF TrkB-full receptor and NFG TrkA receptor levels increased during the follow-up whereas BDNF TrkB-truncated form receptor decreased. After adjusting for confounding variables, baseline levels of proinflamatory variables were significantly related to TrkB-full/TrkB-truncated ratio (FL/T), suggesting that a higher proinflammatory status is related to a higher FL/T ratio expression. Furthermore, baseline FL/T ratio could have a predictor role of patient's functionality 1 year after the illness onset, depending on whether patient is treated or not with antipsychotic drugs.

Conclusion

Inflammatory processes, neurotrophic pathways and functional status of FEP patients seem to be related which is of great traslational relevance. Specific, the expression of the 2 isoforms of BDNF receptor should be taken into account before starting an antipsychotic drug treatment.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW539
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. s258
Copyright
Copyright © European Psychiatric Association 2014
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