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Movement, mood and cognition: Preliminary insight into the effects of electroconvulsive therapy in depression through a data-driven resting-state connectivity analysis

Published online by Cambridge University Press:  13 August 2021

J.-B. Belge ,
P. Mulders ,
J. Van Oort ,
L. Van Diermen ,
P. De Timary ,
E. Constant ,
P. Sienaert ,
D. Schrijvers ,
B. Sabbe  and
P. Van Eijndhoven
J.-B. Belge*
Affiliation:
Adult Psychiatry, Antwerp University, Antwerp, Belgium
P. Mulders
Affiliation:
Psychiatry, Radboud University, Nijmegen, Netherlands
J. Van Oort
Affiliation:
Psychiatry, Radboud University, Nijmegen, Netherlands
L. Van Diermen
Affiliation:
Adult Psychiatry, Antwerp University, Antwerp, Belgium
P. De Timary
Affiliation:
Psychiatry, Université Catholique de Louvain, Brussels, Belgium
E. Constant
Affiliation:
Psychiatry, Université Catholique de Louvain, Brussels, Belgium
P. Sienaert
Affiliation:
Psychiatry, UPC KU Leuven, Kortenberg, Belgium
D. Schrijvers
Affiliation:
Adult Psychiatry, Antwerp University, Antwerp, Belgium
B. Sabbe
Affiliation:
Adult Psychiatry, Antwerp University, Antwerp, Belgium
P. Van Eijndhoven
Affiliation:
Psychiatry, Radboud University, Nijmegen, Netherlands
*
*Corresponding author.

Abstract

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Introduction

ECT is an effective treatment for depression. Beyond its therapeutic effect on mood it has a unique impact on psychomotor and cognitive symptoms.Its mechanism of action remains still unclear. To investigate this, we set out to study the brain’s response to ECT from a large-scale brain-network perspective.

Objectives

The aim of this study was to investigate changes in resting-state functional connectivity following ECT at the whole brain, between-network and within-network level, in patients with a depressive episode.

Methods

Resting-state FMRI data were collected from 17 patients with depression before and after an ECT course. Using a group independent component analysis approach, we focused on four networks that are known to be affected in depression: the salience network (SN), default mode network (DMN), cognitive executive network (CEN) and a subcortical network (SCN). Clinical measures including mood, cognition and psychomotor symptoms were assessed.

Results

ECT increased connectivity of the left CEN with the left angular gyrus and left middle frontal gyrus. An increase in left CEN within network connectivity was observed. Both the right CEN and the SCN showed increased connectivity with the precuneus. Furthermore, the anterior DMN showed increased connectivity with the left amygdala. Finally, improvement of psychomotor retardation was positively correlated with an increase of within-posterior DMN connectivity.

Conclusions

We demonstrate that ECT induces a significant increase of connectivity at both the whole brain and within-network level. Furthermore, we provide first evidence on the association between an increase of within posterior DMN connectivity and an improvement of psychomotor retardation, a core symptom of depression.

Disclosure

No significant relationships.

Keywords

NeuroimagingElectroconvulsive therapyIndependent Component Analysispsychomotor symptoms
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S128
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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