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Leukopenia in clozapine treated patients may be induced by other drugs: a case series

Published online by Cambridge University Press:  16 April 2020

Mary Jo Imbarlina ,
Sonali Sarkar ,
Shashi Marwah ,
Haranath Parepally ,
Phillip R. Johnston ,
Jaspreet S. Brar  and
K.N. Roy Chengappa
Mary Jo Imbarlina
Affiliation:
Special Studies Center at Mayview State Hospital
Sonali Sarkar
Affiliation:
Special Studies Center at Mayview State Hospital Western Psychiatric Institute & Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA15213-2593, USA
Shashi Marwah
Affiliation:
Special Studies Center at Mayview State Hospital
Haranath Parepally
Affiliation:
Special Studies Center at Mayview State Hospital Western Psychiatric Institute & Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA15213-2593, USA
Phillip R. Johnston
Affiliation:
Western Psychiatric Institute & Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA15213-2593, USA
Jaspreet S. Brar
Affiliation:
Western Psychiatric Institute & Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA15213-2593, USA
K.N. Roy Chengappa*
Affiliation:
Special Studies Center at Mayview State Hospital Western Psychiatric Institute & Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA15213-2593, USA
*
*Corresponding author. Western Psychiatric Institute & Clinic, University of Pittsburgh, School of Medicine, 3811 O’Hara Street, Pittsburgh, PA 15213-2593, USA. Email address: chengappakn@msx.upmc.edu
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Abstract

The combination of clozapine and other potentially leukopenic drugs may pose a greater risk for neutropenia. However, neutropenia may not always be due to clozapine. When adding potentially leukopenic drugs, clinicians should look for possible alternatives especially as clozapine is often a drug used as the last resort in treatment refractory schizophrenia.

Keywords

LeukopeniaClozapineAgranulocytosisHematopoiesisSchizophrenia
Type
Short communication
Information
European Psychiatry , Volume 19 , Issue 8 , December 2004 , pp. 506 - 509
Copyright
Copyright © European Psychiatric Association 2004

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References

Alvir, JMLieberman, JASafferman, AZSchwimmer, JLSchaaf, JA.Clozapine- induced agranulocytosis: incidence and risk factors in the United States. N Engl J Med 1993;329:162–7.CrossRefGoogle ScholarPubMed
Brenner, LO. Agranulocytosis and ranitidine (Letter). Ann Intern Med 1986;104:896–7.CrossRefGoogle Scholar
Capellari, GGaio, ACavallaro, ACardaioli, CSimioni, LLa Valle, R, et al. Use of colony stimulating factors for the treatment of drug-induced agranlocytosis. Br J Haematol 1993;84:183–4.CrossRefGoogle Scholar
Devinsky, OHonigfeld, GPatin, J.Clozapine related seizures. Neurology 1991;41:369–71.CrossRefGoogle ScholarPubMed
Facciola, GAvenoso, AScordo, MGAldo, GVentimiglia, APerucca, E, et al. Small effects of valprotic acid on the plasma concentrations of clozapine and its major metabolites in patients with schizophrenic or affective disorders. Ther Drug Monit 1999;21:341–7.CrossRefGoogle ScholarPubMed
Finley, PWarner, D.Potential impact of valproic acid therapy on clozapine disposition. Biol Psychiatry 1994;36:487–8.CrossRefGoogle ScholarPubMed
Kando, JCTohen, MCastillo, JCentorrino, F.Concurrent use of clozapine and valproate in affective and psychotic disorders. J Psychiatry 1994;55:255–7.Google ScholarPubMed
Kane, JHonigfeld, GSinger, JMeltzer, H.Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiatry 1988;45:789–96.CrossRefGoogle ScholarPubMed
Lane, GPSpeed, B.Agranulocytosis after ranitidine administration. Med J Aust 1989;150:595–6.CrossRefGoogle ScholarPubMed
Madeb, RHirschmann, SKurs, RTurkie, AModai, I.Combined clozapine and valproic acid treatment induced agranulocytosis. Eur Psychiatry 2002;17:238–9.CrossRefGoogle ScholarPubMed
Patton, WN. Use of colony stimulating factors in the treatment of drug-induced agranulocytosis. Br J Haematol 1993;84:184–5.Google Scholar
Patton, WPHolyoake, TLYates, JMBoughton, BJFranklin, IM.Accelerated recovery from drug-induced agranulocytosis following G-CSF therapy. Br J Haematol 1992;80:564–5.CrossRefGoogle ScholarPubMed
Peacock, LGerlach, J.Clozapine treatment in Denmark: concomitant psychotropic medication and hematologic monitoring in a system with liberal usage practices. J Clin Psychiatry 1994;55:44–9.Google Scholar
Senechal, ALandry, PDeschamps, RLessard, M.Neutropenia in a patient treated with clozapine in combination with other psychotropic drugs. Encephale 2002;28:567–9.Google Scholar
Shields, LIFiles, JADoll, DCGreensburg, BR.Ranitidine and agranu-locytosis (Letter). Ann Intern Med 1986;104:128.Google Scholar
Watts, RGEmanuel, PDSucherman, KSHoward, TH.Valproic acid induced cytopenia: evidence for a dose-related suppression of hematopoiesis. J Pediatr 1990;117:495–9.CrossRefGoogle Scholar
Wilson, WH. Do anticonvulsants hinder clozapine treatment? Biol Psychiatry 1995;37:132–3.CrossRefGoogle ScholarPubMed
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