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Is there an association between the COMT gene and P300 endophenotypes?

Published online by Cambridge University Press:  16 April 2020

E. Bramon*
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
E. Dempster
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
S. Frangou
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
C. McDonald
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
P. Schoenberg
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
J.H. MacCabe
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
M. Walshe
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
P. Sham
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
D. Collier
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
R.M. Murray
Affiliation:
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK
*
*Corresponding author. Tel.: +44 207 848 5036; fax: +44 207 701 9044. E-mail address:e.bramon@iop.kcl.ac.uk (E. Bramon).
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Abstract

P300 wave anomalies correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The COMT gene is thought to influence cognitive performance and to be a susceptibility gene for schizophrenia. Unlike two previous studies, we found no significant influence of the COMT gene on P300 amplitude or latency in 189 individuals examined. The well-supported role of the COMT gene both in dopamine catabolism as well as in prefrontal cognition makes a strong theoretical case for the influence of COMT Val158Met polymorphism on P300 endophenotypes. However, the available neurophysiologic evidence suggests that any such association, if present, must be very subtle.

Type
Original article
Copyright
Copyright © Elsevier SAS 2006

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