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The influence of genetic polymorphisms on white matter lesion load in dementia

Published online by Cambridge University Press:  16 April 2020

P. Kelemen ,
H. Kölsch ,
R. Heun ,
R. Seitz ,
B. Krumm ,
L. Frölich  and
F. Hentschel
P. Kelemen
Affiliation:
Department of Neroradiology, CIMH, Mannheim, Germany
H. Kölsch
Affiliation:
Moleculargenetic Laboratory, Clinic of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
R. Heun
Affiliation:
Moleculargenetic Laboratory, Clinic of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
R. Seitz
Affiliation:
Department of Neroradiology, CIMH, Mannheim, Germany
B. Krumm
Affiliation:
Department of Biostatistics, CIMH, Mannheim, Germany
L. Frölich
Affiliation:
Department of Gerontopsychiatry, CIMH, Mannheim, Germany
F. Hentschel
Affiliation:
Department of Neroradiology, CIMH, Mannheim, Germany

Abstract

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Introduction:

Ischemic neuronal disintegration of the brain tissue is a main risk factor for the development of a vascular dementia (VD). Because of the complexity of cerebrovascular and other factors it is not possible to describe the whole variance of the incidence of VD merely by genetic polymorphisms, however they may explain a part of the complexity. Nevertheless there is hope to identify the contribution of genetic markers in VD.

Material and methods:

Data of clinically, neuropsychologically, neuroradiologically and genetically examined patients (n = 236) of a memory clinic were analysed upon the interrelation of clinical diagnosis according to ICD-10 and genetics, differentiated in the diagnostic groups: cognitively healthy persons (XD, n=65), VD (n=56) and Alzheimer´s Disease (AD, n=115).

Comparison of groups was done using descriptive statistics and analysis of variance.

Results:

The VD group (n=56) was genetically different compared to both groups, patients with Alzheimer disease (AD, n=115) and cognitively healthy persons (XD, n=65). For VD, there was a statistically significant correlation between some genetic markers and wmL load.

Conclusion:

Regarding procentual frequency of the polymorphisms genetic pattern in patients with VD are different to XD but not to the AD group.

The wmL load is higher in VD and AD then in XD.

In general, the results are arguments against dichotomy and for the hypothesis of interaction between VD and AD in older age.

Type
Poster Session 2: Organic Mental Disorders and Memory and Cognitive Dysfunctions
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S301
Copyright
Copyright © European Psychiatric Association 2007
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