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Incidence and Risk Factors of Psychotic Disorders. a Comparison of Northern Finland Birth Cohorts 1966 and 1986

Published online by Cambridge University Press:  15 April 2020

S. Filatova
Affiliation:
Psychiatry, Institute of Clinical Medicine University of Oulu, Oulu, Finland
R. Marttila
Affiliation:
Psychiatry, Institute of Clinical Medicine University of Oulu, Oulu, Finland
T. Nordström
Affiliation:
Psychiatry, Institute of Clinical Medicine University of Oulu, Oulu, Finland
J. Veijola
Affiliation:
Psychiatry, Institute of Clinical Medicine University of Oulu, Oulu, Finland
P. Mäki
Affiliation:
Psychiatry, Institute of Clinical Medicine University of Oulu, Oulu, Finland
P.B. Jones
Affiliation:
Psychiatry, University of Cambridge, Cambridge, United Kingdom
G.K. Murray
Affiliation:
Psychiatry, University of Cambridge, Cambridge, United Kingdom
M. Isohanni
Affiliation:
Psychiatry, Institute of Clinical Medicine University of Oulu, Oulu, Finland
E. Jääskeläinen
Affiliation:
Psychiatry, Institute of Health Sciences, Oulu, Finland
H. Koivumaa-Honkanen
Affiliation:
Psychiatry, University of Eastern Finland, Kuopio, Finland
K. Moilanen
Affiliation:
Psychiatry, Institute of Clinical Medicine University of Oulu, Oulu, Finland
J. Miettunen
Affiliation:
Psychiatry, Institute of Clinical Medicine University of Oulu, Oulu, Finland

Abstract

Introduction

There are limited amount of studies comparing time trends of incidence and risk factors of psychosis.

Objectives

To compare time trends of incidence of psychosis in two population samples.

Aims

To study 1) onset age and cumulative incidence of psychoses in two Northern Finland Birth Cohorts (NFBC), 2) changes in type of diagnosis and risk factors.

Methods

The NFBC 1966 (N=12,058) and NFBC 1986 (N=9,432) are prospective cohorts of the two provinces of Finland with the live born children followed since pregnancy. The data for psychosis and risk factors were collected from variety of nationwide registers and earlier collected data of the NFBCs. The follow-up time was in both cohorts in average 26.5 years.

Results

Proportion of all psychoses was higher in NFBC 1986 than in the NFBC 1966 (1.81% vs 1.0%). There were more affective psychoses in NFBC 1986 (0.5% vs 0.1%), but incidence of schizophrenia was the same (0.4%) in both cohorts. The age of onset was lower in NFBC 1986 than in NFBC 1966 and majority of this cases were females. Only parental psychosis was a significant risk factor predicting psychosis (Hazard Ratios >3.0) in both cohorts.

Conclusions

In conclusion, two birth cohorts within 20 years covering altogether about 40 years showed changes in terms of incidence, age of onset, and type of psychosis.

Type
Article: 0223
Copyright
Copyright © European Psychiatric Association 2015
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