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Genes and neurocognitive performance: are the two related in adult ADHD?

Published online by Cambridge University Press:  16 April 2020

A.M. Boonstra ,
J.S. Kooij ,
J.K. Buitelaar ,
J. Oosterlaan ,
J.A. Sergeant ,
J.G. Heister  and
B. Franke
A.M. Boonstra
Affiliation:
Institute of Psychology, Erasmus University, Rotterdam, The Netherlands
J.S. Kooij
Affiliation:
Department of Adult ADHD, Parnassia Psycho-Medical Center, Den Haag, The Netherlands
J.K. Buitelaar
Affiliation:
Department of Psychiatry, University Medical Center St. Radboud, Nijmegen, The Netherlands
J. Oosterlaan
Affiliation:
Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands
J.A. Sergeant
Affiliation:
Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands
J.G. Heister
Affiliation:
Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
B. Franke
Affiliation:
Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

Abstract

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Background and Aims

Studies in children suggest that neurocognitive performance is a possible endophenotype for ADHD. We wished to establish a first connection between key genetic polymorphisms and neurocognitive performance in adults with ADHD.

Methods

We genotyped 45 adults with ADHD at four key candidate polymorphisms for the disorder (DRD4 48 bp repeat, DRD4 120 bp duplicated repeat, SLC6A3 40 bp VNTR, and COMT Val158Met). We then sub-grouped the sample for each polymorphism by genotype or by the presence of the (putative) ADHD risk allele and compared the performance of the subgroups on a large battery of neurocognitive tests.

Results

The COMT Val158Met polymorphism was related to differences in IQ and reaction time, both of the DRD4 polymorphisms (48 bp repeat and 120 bp duplication) showed an association with verbal memory skills, and the SLC6A3 40 bp VNTR polymorphism could be linked to differences in inhibition.

Conclusions

Our findings contribute to the complicated search for possible endophenotypes for (adult) ADHD.

Type
S41. Symposium: Genes, Endophenotypes and Treatment of Adult ADHD
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S62 - S63
Copyright
Copyright © European Psychiatric Association 2007
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