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Genes and alcohol

Published online by Cambridge University Press:  16 April 2020

U. Ösby ,
J. Liljenberg ,
I. Kockum ,
A. Gunnar  and
L. Terenius
U. Ösby
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital, L8:01, SE-171 76Stockholm, Sweden
J. Liljenberg
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital, L8:01, SE-171 76Stockholm, Sweden
I. Kockum
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital, L8:01, SE-171 76Stockholm, Sweden
A. Gunnar
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital, L8:01, SE-171 76Stockholm, Sweden
L. Terenius*
Affiliation:
Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital, L8:01, SE-171 76Stockholm, Sweden
*
*Corresponding author. Tel.: +46 8 517 748 50; fax: +46 8 34 19 39. E-mail address: Lars.Terenius@ki.se (L. Terenius).
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Abstract

The negative effects of excessive alcohol use include dependence, psychiatric co-morbidity and increased risk for suicide. A dominating risk factor is heritage. A large number of studies have addressed the genetic basis, either “candidate genes” in the brain reward system, or searched for unknown genes in family studies by linkage analysis. It is clear that no single gene polymorphism is of use in preventive medicine. A consistent finding, however, is that polymorphism in the alcohol dehydrogenase cluster and other metabolic pathways are of some relevance on a population basis, suggesting a link between alcohol toxicity in general and dependence. An emerging concern is potential gender differences as women, who are generally more sensitive, acquire male drinking habits.

Keywords

AlcoholSuicideBiostatisticsEmergencyGenetics
Type
Original article
Information
European Psychiatry , Volume 25 , Issue 5: The role of genetics in promoting suicide prevention and the mental health of the population - Nobel Conference: The role of genetics in promoting suicide prevention and the mental health of the population , June 2010 , pp. 281 - 283
Copyright
Copyright © Elsevier Masson SAS 2010

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