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Dosage of antipsychotics in China routine practice

Published online by Cambridge University Press:  13 August 2021

T. Zhang*
Affiliation:
Epidemiology, Janssen Research and Development, Beijing, China
R. Chi
Affiliation:
Peking University The Sixth Hospital, Institute Of Mental Health; National Clinical Research Center For Mental Health Disorders & Key Laboratory Of Mental Health, Ministry Of Health, Peking University, Peking University the Sixth Hospital, Beijing, China
T. Wu
Affiliation:
Epidemiology, Janssen Research and Development, Beijing, China
Y. Xu
Affiliation:
Peking University The Sixth Hospital, Institute Of Mental Health; National Clinical Research Center For Mental Health Disorders & Key Laboratory Of Mental Health, Ministry Of Health, Peking University, Peking University the Sixth Hospital, Beijing, China
W. Dong
Affiliation:
Peking University The Sixth Hospital, Institute Of Mental Health; National Clinical Research Center For Mental Health Disorders & Key Laboratory Of Mental Health, Ministry Of Health, Peking University, Peking University the Sixth Hospital, Beijing, China
*
*Corresponding author.

Abstract

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Introduction

The antipsychotic dosage of Chinese schizophrenia patients has rarely been studied, although nonstandard dosage has impact on prognosis.

Objectives

To describe the dosage of antipsychotics in China routine practice.

Methods

This was a retrospective cohort study using de-identified data from a Chinese mental health hospital. The included patients were adults (≥18 years) with at least one diagnosis of schizophrenia (ICD-10: F20) and one prescription of any antipsychotic between 2014 and 2019. Date of first identified antipsychotic prescription was defined as index date, patients were followed up until last prescription of antipsychotics, end of 2019, or discontinuation (>60 days without antipsychotic prescription), whichever was earliest. Dosage was summarized using defined daily dose (DDD), calculated by cumulative average daily dose (CAD) with a unit of DDDs/day, i.e., total DDDs of all antipsychotics in follow-up period divided by total days of follow-up. CAD was categorized into low (<0.5 DDDs/day), moderate (0.5-1.5 DDDs/day), and high (>1.5 DDDs/day) groups.

Results

13554 patients were included with an average follow-up of 269.9 days. Median CAD was 0.8 DDDs/day (IQR=0.5-1.3), patients with hospitalization during follow-up and used multiple antipsychotics at the same time had larger median CAD, 1.0 DDDs/day and 1.2 DDDs/days, respectively. There were 3245 (23.9%), 7627 (56.3%), and 2682 (19.8%) patients in low, moderate, and high groups, respectively. The median CAD of high dosage group was 2.5 DDDs/day (IQR=1.9-10.5).

Conclusions

CAD of most Chinese schizophrenia patients was low or moderate. Association between CAD and hospitalization and multiple concurrent antipsychotics merit further research.

Type
Abstract
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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