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Cortical metabolic patterns in schizophrenia: a mismatch with the positive-negative paradigm

Published online by Cambridge University Press:  16 April 2020

JD Huret ,
BM Mazoyer ,
A Lesur ,
JL Martinot ,
S Pappata ,
JC Baron ,
T Lemperière  and
A Syrota
JD Huret
Affiliation:
Service Hospitalier Friédéric Joliot, Département de Biologie, Commissariat à l'Énergie Atomique, 91406Orsay
BM Mazoyer
Affiliation:
Service Hospitalier Friédéric Joliot, Département de Biologie, Commissariat à l'Énergie Atomique, 91406Orsay
A Lesur
Affiliation:
Service Hospitalier Friédéric Joliot, Département de Biologie, Commissariat à l'Énergie Atomique, 91406Orsay
JL Martinot
Affiliation:
Service Hospitalier Friédéric Joliot, Département de Biologie, Commissariat à l'Énergie Atomique, 91406Orsay
S Pappata
Affiliation:
Service Hospitalier Friédéric Joliot, Département de Biologie, Commissariat à l'Énergie Atomique, 91406Orsay
JC Baron
Affiliation:
Service Hospitalier Friédéric Joliot, Département de Biologie, Commissariat à l'Énergie Atomique, 91406Orsay
T Lemperière
Affiliation:
Service de Psychiatrie, Hôpital Louis Mourier, 92700Colombes, France
A Syrota
Affiliation:
Service Hospitalier Friédéric Joliot, Département de Biologie, Commissariat à l'Énergie Atomique, 91406Orsay
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Summary

The cortical metabolic patterns of 12 schizophrenics experiencing hallucinations and/or pseudo-hallucinations were investigated using positron tomography and 18F-fluoro-deoxy-glucose. Andreasen's scales were scored and the patients (all “mixed“) were classified in a “positive” or a “negative” group and compared to a group of 6 normal controls. The data were analyzed across groups for absolute metabolic rates, metabolic indices (cortical region/whole studied cortex), and specific indices exploring the sensory non-association/posterior parietal association and the prefrontal association/posterior parietal association dimensions. Whole-cortex metabolic rate in the negative group was found to be lower than both the control (P=0.02) and the positive group (P = 0.002) while the positive group did not differ significantly from the controls. We found “hypofrontality” to be without difference between the positive and the negative group (controls: 7±0.7, positive: 5.9±0.2, negative: 4.9±0.15, mean±SEM in mg/min/100 g). However, the prefrontal association/posterior parietal association ratio was increased in the negative group (P=0.02). A major finding was an increase in the posterior non-association/posterior parietal association ratio in the whole schizophrenic group as compared to the controls (P = 0.004), this being more marked in the negative (P=0.01) than in the positive group. Arguments are given to support the hypothesis that this particular increase could be related to the hallucinatory activity of the patients.

Keywords

cortical metabolic patternsschizophreniahallucinationpositron tomography18F-fluoro-deoxyglucose
Type
Original article
Information
European Psychiatry , Volume 6 , Issue 1 , 1991 , pp. 7 - 19
Copyright
Copyright © Elsevier, Paris 1991

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