Given the increase in depressive symptoms, as a mental disorder combined with an organic disease, we suggest a therapeutic approach based on group therapy. The effectivity of this kind of therapy has been confirmed by multiple studies as a way to decrease the pressure in mental health units. The results reached in various studies confirm at least an equal effectivity as individual psychotherapy, thereby it optimizes the increasingly limited public health resources. The objective of the group therapy is to promote an active attitude in the patients and make them responsible of their condition and their treatment process too. The program is aimed to female patients with various kinds of clinical depression, ranging from 40 to 60, who come to the USMC Hospital Vazquez Diaz in Huelva. The group had 12 participants, it was led by a Clinical Psychologist with the help of the Clinical Psychology residents. The program consisted in 8 bimonthly sessions of 90 minutes with an assessment test/retest at the beginning and end of it. The work in the group therapy was based on the constructivist orientation. Different areas were treated as: identification and adaptive expression of emotions, strengthening self-esteem and providing adaptive coping strategies to the psychological distress. As a conclusion we can see how the individual changes in the patients go socializing and enhancing the change in the rest of the participants in a mutual support that promote a more active role that take the patients away of the initial passivity.