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Are depression and denutrition good predictors of dexamethasone suppression test (DST) in anorexia nervosa?

Published online by Cambridge University Press:  16 April 2020

C Massoubre ,
F Lang ,
L Millot ,
M Pichon ,
B Estour  and
J Pellet
C Massoubre
Affiliation:
Groupe de Recherche sur les Troubles de Conduite Alimentaire, Faculté de Médecine42023Saint Etienne cedex 2, France
F Lang
Affiliation:
Groupe de Recherche sur les Troubles de Conduite Alimentaire, Faculté de Médecine42023Saint Etienne cedex 2, France
L Millot
Affiliation:
Groupe de Recherche sur les Troubles de Conduite Alimentaire, Faculté de Médecine42023Saint Etienne cedex 2, France
M Pichon
Affiliation:
Groupe de Recherche sur les Troubles de Conduite Alimentaire, Faculté de Médecine42023Saint Etienne cedex 2, France
B Estour
Affiliation:
Groupe de Recherche sur les Troubles de Conduite Alimentaire, Faculté de Médecine42023Saint Etienne cedex 2, France
J Pellet
Affiliation:
Groupe de Recherche sur les Troubles de Conduite Alimentaire, Faculté de Médecine42023Saint Etienne cedex 2, France
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Summary

This study was conducted to investigate the corticotropic axis in anorexia nervosa. In 93 female inpatients who met DSM-III-R criteria for anorexia nervosa, subsample (n = 64) with DSM-III criteria was also considered. Using stepwise regression analysis, this study examined the relationship between independent variables ie, age, body mass index, scores on depression scales and postdexamethasone serum cortisol, considered as a dependent variable. In patients who met DSM-III criteria, 16.7% of the variance of serum cortisol can be explained. The main predictors are depressive retardation, emaciation and age. Using stepwise logistic regression the main categorical predictors of the test suppression vs non suppression are of the same nature. The condition of realisation of DST are discussed.

Keywords

anorexia nervosadexamethasone testdenutritiondepression
Type
Research Article
Information
European Psychiatry , Volume 13 , Issue 8 , December 1998 , pp. 411 - 418
Copyright
Copyright © Elsevier, Paris 1998

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