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P0140 - Age at onset in bipolar disorders

Published online by Cambridge University Press:  16 April 2020

A. Ortiz-Dominguez
Affiliation:
Deparment of Psychiatry, McGill University, Montreal, QC, Canada
C. Slaney
Affiliation:
Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
J. Garnham
Affiliation:
Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
M. Alda
Affiliation:
Deparment of Psychiatry, McGill University, Montreal, QC, Canada Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
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Abstract

Background:

The underlying genetic heterogeneity in Bipolar Disorder (BD) has led to the search of potential markers associated with subtypes of the disorder; as such, age at onset (AAO) could be considered as a factor that defines more genetically homogeneous subgroups.

Objective:

To analyze the modal distribution of a BD population according to the AAO of the disorder, as well as the clinical characteristics related to the distribution findings.

Methods:

357 patients with a BD diagnosis were included in the study. AAO was defined as the age when the patient first met DSM-IV criteria for a major mood episode. Using an admixture analysis, patients were distributed among different parameters; and parametric analyses were conducted in order to compare the demographic and clinical characteristics between groups.

Results:

The model that best fit the observed distribution was a mixture of three Gaussian distributions (mean ± SD): 17±3.7 years, 26±8.8 years, and 35.5±12.54 years. Statistically significant differences were found with respect to social status, course of illness, suicidal behavior, rapid cycling, medical co-morbidities and lithium response (p<0.05).

Conclusions:

Our results support the existence of a tri-modal distribution in BD defined by AAO, each one with different clinical characteristics; and suggest that early-onset and late-onset BD reflect an underlying genetic heterogeneity in bipolar disorder, being early-onset BD implicitly a more serious subtype of disorder.

Type
Poster Session II: Bipolar Disorders
Copyright
Copyright © European Psychiatric Association 2008

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