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Incidence rate and morphyology of cavum septum pellucidum in patients with treatment-resistant schizophrenia, major depression: A structural MRI study

Published online by Cambridge University Press:  16 April 2020

J. Sun
Affiliation:
Children and Adolescent Department, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
J.J. Maller
Affiliation:
Department of Psychiatry, Monash Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology and Psychiatry, Melbourne, VIC, Australia
L. Guo
Affiliation:
Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China
Z.J. Daskalakis
Affiliation:
Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
P.B. Fitzgerald
Affiliation:
Department of Psychiatry, Monash Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology and Psychiatry, Melbourne, VIC, Australia
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Abstract

Introduction

Several studies have independently suggested that schizophrenia patients are more likely to have an enlarged cavum septum pellucidum (CSP). However, neither finding has been consistently replicated.

Objectives

We recruited the relatively homogeneity population: treatment resistant schizophrenia (TRS) and treatment resistant depression (TRD).To investigate whether CSP was present more frequently in TRS or TRD patients than controls and the difference of CSP morphological characteristic between groups.

Methods

1.5-Tesla MRI was used to evaluate the prevalence of CSP and morphology changes in 42 TRS, 45 TRD patients and 30 healthy controls. The CSP length, width and volume were measured using MRIcro and Analyze 8.1 software. A CSP equal to or greater than 6 mm in length was defined as big CSP.

Results

TRS Patients had a significantly higher prevalence (6%) of the big CSP than TRD patients (0%) or controls (3.3%) while no significant difference on the prevalence of all CSP (TRS: 64.3%, TRD: 48.9%, controls: 50.0%) or small CSP between groups. Compared with controls or TRD patients, the values of CSP maximum width in patients with TRS were significant lower and CSP length were higher. There was no significant difference in the CSP volume between groups.

Conclusions

The incidence in Big CSP in TRS patients was higher than that of TRS patients or controls. The small CSP may be a kind of normal variant. There were different CSP developmental characteristics between TRS and TRD patients based on the MRI study.

Type
P02-359
Copyright
Copyright © European Psychiatric Association 2011

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Incidence rate and morphyology of cavum septum pellucidum in patients with treatment-resistant schizophrenia, major depression: A structural MRI study
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Incidence rate and morphyology of cavum septum pellucidum in patients with treatment-resistant schizophrenia, major depression: A structural MRI study
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Incidence rate and morphyology of cavum septum pellucidum in patients with treatment-resistant schizophrenia, major depression: A structural MRI study
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