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Fringe phenotypes in autism: a review of clinical, biochemical and cognitive studies

Published online by Cambridge University Press:  16 April 2020

Véronique Goussé
Affiliation:
Consultation autisme, service de psychopathologie de l’enfant et de l’adolescent, hôpital Robert Debré, assistance publique-hôpitaux de Paris, 75019 Paris, France INSERM U 513, hôpital Henri Mondor, 94000 Créteil, France
Marie-Hélène Plumet
Affiliation:
Consultation autisme, service de psychopathologie de l’enfant et de l’adolescent, hôpital Robert Debré, assistance publique-hôpitaux de Paris, 75019 Paris, France
Nadia Chabane
Affiliation:
Consultation autisme, service de psychopathologie de l’enfant et de l’adolescent, hôpital Robert Debré, assistance publique-hôpitaux de Paris, 75019 Paris, France INSERM U 513, hôpital Henri Mondor, 94000 Créteil, France
Marie-Christine Mouren-Siméoni
Affiliation:
Consultation autisme, service de psychopathologie de l’enfant et de l’adolescent, hôpital Robert Debré, assistance publique-hôpitaux de Paris, 75019 Paris, France
Nathalie Ferradian
Affiliation:
Service de psychiatrie, hôpital Albert Chenevier et Henri Mondor, assistance publique-hôpitaux de Paris, 40, rue de Mesly, 94000 Créteil, France
Marion Leboyer
Affiliation:
Consultation autisme, service de psychopathologie de l’enfant et de l’adolescent, hôpital Robert Debré, assistance publique-hôpitaux de Paris, 75019 Paris, France INSERM U 513, hôpital Henri Mondor, 94000 Créteil, France Service de psychiatrie, hôpital Albert Chenevier et Henri Mondor, assistance publique-hôpitaux de Paris, 40, rue de Mesly, 94000 Créteil, France
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Summary

Progress in identifying the genetic vulnerability factors in autism requires correct identification of the inherited phenotype(s). This can be achieved not only by the accurate description of the affected subject but also by the identification of vulnerability traits in non-affected relatives of autistic probands. This review will focus on this last strategy and principally on clinical, biochemical and cognitive traits.

Type
Review
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS. 2002

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