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EPA-1537 - Clinical Predictors of Non-response in 253 Patients with Treatment Resistant-depression

Published online by Cambridge University Press:  15 April 2020

G. Di Lorenzo
Affiliation:
Department of Systems Medicine University of Rome “Tor Vergata”, Chair of Psychiatry, Roma, Italy
Y. Barone
Affiliation:
Department of Systems Medicine University of Rome “Tor Vergata”, Chair of Psychiatry, Roma, Italy
A. Daverio
Affiliation:
Department of Systems Medicine University of Rome “Tor Vergata”, Chair of Psychiatry, Roma, Italy
E. Bianciardi
Affiliation:
Department of Systems Medicine University of Rome “Tor Vergata”, Chair of Psychiatry, Roma, Italy
M. Ribolsi
Affiliation:
Department of Systems Medicine University of Rome “Tor Vergata”, Chair of Psychiatry, Roma, Italy
C. Niolu
Affiliation:
Department of Systems Medicine University of Rome “Tor Vergata”, Chair of Psychiatry, Roma, Italy
A. Siracusano
Affiliation:
Department of Systems Medicine University of Rome “Tor Vergata”, Chair of Psychiatry, Roma, Italy
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Abstract

Introduction

Treatment Resistant-Depression (TRD), known as the failure to respond to at least two different adequate trials of antidepressant treatments (ADT) in the current episode, is a relatively frequent clinical condition, associated to a high number of relapses, hospitalizations, and an elevated use of multiple pharmacological treatments. To date, however, the association between clinical variables and non-response in TRD remains unclear.

Objectives

To identify predictors of non-response in inpatients with Major Depressive Disorder (MDD) and TRD.

Aims

To investigate clinical variables as potential predictors of non-response in TRD.

Methods

Two hundred fifty-three inpatients with MDD and TRD were divided into two groups: responders and non-responders to drug therapies, according to a decrease of 50% or more of the severity of depression (measured with HAM-D 17 items) at the end of forth week of hospitalization. A general model of Cox regression (with backward stepwise method) was used to identify independent predictors of non-response to treatment.

Results

One hundred fifty-four TRD inpatients were responders and 99 non-responders. Cox regression identified three independent clinical predictors independently associated with the group of non-responders: (1) the presence of 5 or more depressive episodes in the medical history (OR = 2.27); (2) a current comorbid anxiety disorder (OR = 1.85); (3) a history of early life adversities (ELAs) (OR = 1.60).

Conclusions

The findings of this study suggest that the phenomenon of non-pharmacological response in the TRD is associated with different clinical variables, which might act through separate mechanisms in determining the persistence of depressive symptomatology.

Type
E02 - e-Poster Oral Session 02: Depression and Suicide
Copyright
Copyright © European Psychiatric Association 2014

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