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BDNF Val66Met modulates 5-HTTLPR for develop neuroticism in borderline personality disorder

Published online by Cambridge University Press:  16 April 2020

J. Villarroel Garrido
Affiliation:
Mental Health and Psychiatry, Santiago, Chile
H. Silva Ibarra
Affiliation:
Mental Health and Psychiatry, Santiago, Chile
P. Iturra Constant
Affiliation:
Human Genetics Program, Universidad de Chile, Santiago, Chile
S. Jerez Concha
Affiliation:
Mental Health and Psychiatry, Santiago, Chile
C. Montes Aguirre
Affiliation:
Mental Health and Psychiatry, Santiago, Chile
M. Fuentes Salgado
Affiliation:
Mental Health and Psychiatry, Santiago, Chile
M.L. Bustamante Calderon
Affiliation:
Mental Health and Psychiatry, Santiago, Chile
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Abstract

Brain derived neurotrophic factor (BDNF) is the most widely distributed and highly expressed neurotrophin in the CNS. BDNF gene have been associated with increased risk psychiatric disorders. It has been described interaction between BDNF and serotonin system at a neural and genetic level. Neuroticism as a personality trait relevant in borderline personality disorder (BPD) has genetic inheritance and is associated with serotonergic dysfunction. Has been reported that BDNF Val66Met variant is associated with neuroticism in general population. The aim of this study is to test the association between Val66Met and neuroticism and evaluate if the presence of Val66Met allele interacts with polymorphism in promoter region of serotonin transporter gene (5-HTTLPR) for develop neuroticism in BPD. We evaluate personality with NEO PI R in 104 BPD subjects that did not meet criteria for axis I diagnoses and other personality disorders. Genetic analysis of BDNF was performed determining the presence of Val/Val Val/Met and Met/Met BDNF variants. 5-HTTLPR was performed determining the presence of L and S 5-HTTLPR alleles. Statistical analysis were tested with parametric and correlation method with Stata10. We did not found differences in neuroticism between BDNF variants, but when controlled by BDNF alleles we found that Met/Met modulate the expression of 5-HTTLPR, with S-carriers (LS+SS) having higher neuroticism than LL (F = 6.36, p = 0.0031). We found no differences in expression of 5-HTTLPR in other BDNF variants. We conclude that BDNF have a differential modulating effect of 5-HTTLPR in neuroticism in BPD.

Type
P02-226
Copyright
Copyright © European Psychiatric Association 2011

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