Skip to main content Accessibility help
×
Home
Hostname: page-component-99c86f546-5rzhg Total loading time: 0.21 Render date: 2021-12-07T05:38:54.351Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Article contents

Association of FKBP5 gene haplotypes with completed suicide in the Japanese population

Published online by Cambridge University Press:  16 April 2020

A. Hishimoto
Affiliation:
Kobe University Graduate School of Medicine, Kobe, Japan
T. Sasada
Affiliation:
Kobe University Graduate School of Medicine, Kobe, Japan
M. Fukutake
Affiliation:
Kobe University Graduate School of Medicine, Kobe, Japan
K. Shiroiwa
Affiliation:
Kobe University Graduate School of Medicine, Kobe, Japan
I. Supriyanto
Affiliation:
Kobe University Graduate School of Medicine, Kobe, Japan
O. Shirakawa
Affiliation:
Kinki University School of Medicine, Osaka, Japan
Get access

Abstract

Background

The hypothalamus-pituitary-adrenal (HPA) axis is known to have a role in suicidal behaviors in patients with affective disorders. However, the incomplete overlapping of the genetic factors of suicidal behaviors and the genetic factors of affective disorders suggest that the genes associated with predisposition to suicidal behaviors and affective disorders are different. There is increasing evidence that genes regulating the HPA axis have effects on suicidal behaviors. To test this idea, we examined the association of three HPA axis-related genes (glucocorticoid receptor (NR3C1), mineralocorticoid receptors (NR3C2), and FK506 binding protein 5 (FKBP5)) with suicide.

Methods

We selected 3 SNPs of the FKBP5 (rs3800373, rs1360780, rs2395635), 2 SNPs of the NR3C1 (rs6196, rs10052957), and 3 SNPs of the NR3C2 genes (rs5525, rs5522, rs2070951) based on their frequency in the Japanese population. Using Taqman probe assays, we determined these SNPs in 219 completed suicide victims and 228 age- and gender- matched healthy control subjects.

Results

No significant differences in genotypic distribution or allelic frequency of any single SNPs between the completed suicide and control groups were observed. The distributions of TT, TC, and GT haplotypes of the FKBP5 gene (comprised of rs3800373 and rs1360780) between the completed suicide and control groups were significantly different (p < 0.05 for each haplotype). The TC haplotype withstood correction for multiple comparisons (corrected p = 0.034).

Conclusion

Our results suggest that haplotypes in FKBP5 gene are associated with completed suicide. This finding needs to be confirmed using rigorous SNPs selection in a larger sample.

Type
P03-446
Copyright
Copyright © European Psychiatric Association 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)
Submit a response

Comments

No Comments have been published for this article.

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Association of FKBP5 gene haplotypes with completed suicide in the Japanese population
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Association of FKBP5 gene haplotypes with completed suicide in the Japanese population
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Association of FKBP5 gene haplotypes with completed suicide in the Japanese population
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *