Skip to main content Accessibility help
×
Home
Hostname: page-component-544b6db54f-prt4h Total loading time: 0.209 Render date: 2021-10-21T19:35:10.095Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Article contents

1476 – Factors Associated With Lifetime Antidepressant-induced Mania In Bipolar Disorder Patients

Published online by Cambridge University Press:  15 April 2020

C. Brichant-Petitjean
Affiliation:
CSAPA Espace Murger, Groupe Hospitalier Fernand Widal-Lariboisière
S. Sportiche
Affiliation:
Groupe Hospitalier Saint-Louis Lariboisière Fernand Widal, Inserm U 705 & CNRS UMR 8206, Paris
B. Etain
Affiliation:
Groupe Hopsitalier Henri-Mondor Albert Chenevier Inserm U 955 Psychiatrie Génétique Fondation FondaMental
C. Henry
Affiliation:
Groupe Hopsitalier Henri-Mondor Albert Chenevier U 955 Faculté IFR 10, Créteil
J.-P. Kahn
Affiliation:
Fondation FondaMental CHU Nancy, Nancy
J.-M. Azorin
Affiliation:
Fondation FondaMental CHU Marseille Marseille
L. Marion
Affiliation:
Groupe Hopsitalier Henri-Mondor Albert Chenevier Fondation FondaMental INSERM U 955, Créteil
F. Bellivier
Affiliation:
Groupe Hospitalier Saint-Louis Lariboisière Fernand Widal, Inserm U 705 & CNRS UMR 8206, Paris Fondation FondaMental, Paris, France
Get access

Abstract

Introduction

Antidepressants may induce manic or hypomanic episodes. The identification of predictors of antidepressant- induced mania (AIM) is essential to improve the management of bipolar disorder (BD). However, the rare studies on AIM are generally characterized by small sample sizes, varying definitions of AIM and heterogeneous groups of patients, thus leading to conflicting results.

Objectives

To compare a population of AIM(+) to AIM(-) patients in order to identify specific clinical factors associated with AIM.

Methods

All 252 participants met the DSM-IV criteria for BD. Only patients who reported AIM in the 90 days after the beginning of an antidepressant (with or without a mood stabilizer) were diagnosed as AIM (+) and those without any lifetime history of AIM despite lifetime antidepressant prescription were considered AIM (-). Sociodemographic and clinical factors were collected using the DIGS, ALS, AIS BIS and WURS.

Results

AIM(+) (N=74) and AIM(-) (N=178) patients did not differ significantly in terms of age, gender distribution, bipolar disorder duration and age of onset, ALS, BIS and WURS score. However, the rates of rapid cyclers, lifetime history of suicidal acts, alcohol use disorder and AIS score were significantly higher in the AIM(+)group. The type of polarity of onset was significantly different in both groups.

Conclusions

A history of rapid cycling, of suicidal acts and of alcohol use disorder could be considered as risk factors of AIM in BD. Patients with these factors could therefore be identified as a vulnerable subgroup prone to manic switch with antidepressant.

Type
Research Article
Copyright
Copyright © European Psychiatric Association 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)
Submit a response

Comments

No Comments have been published for this article.

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

1476 – Factors Associated With Lifetime Antidepressant-induced Mania In Bipolar Disorder Patients
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

1476 – Factors Associated With Lifetime Antidepressant-induced Mania In Bipolar Disorder Patients
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

1476 – Factors Associated With Lifetime Antidepressant-induced Mania In Bipolar Disorder Patients
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *