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La respuesta inicial al fármaco activo y al placebo predice la evolución del tratamiento antidepresivo

Published online by Cambridge University Press:  12 May 2020

S. Priebe  and
M. Bröker
S. Priebe
Affiliation:
Departamento de Psiquiatría Social, Universidad Libre de Berlín, Berlín, Alemania
M. Bröker
Affiliation:
Departamento de Psiquiatría Social, Universidad Libre de Berlín, Berlín, Alemania
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Resumen

En este estudio examinamos si el cambio clínico inicial (CCI) y la respuesta subjetiva inicial (RSI) predicen la evolución de la farmacoterapia antidepresiva, y si el CCI y la RSI reflejan acciones farmacológicas específicas o un efecto placebo como predictores. Cuarenta pacientes con depresión mayor fueron tratados con tres antidepresivos diferentes durante 4 semanas. Se tomaron como criterios de evolución el cambio clínico global y la respuesta subjetiva final. Los pacientes fueron asignados al azar a dos subgrupos en un diseño doble ciego. Inicialmente, un grupo recibió el fármaco activo y el otro, placebo. Después, se dio a todos el fármaco activo. Se encontraron correlaciones significativas entre el CCI y la RSI y al menos uno de los criterios de evolución en la muestra total y en cada subgrupo. Los resultados muestran que el CCI y la RSI pueden ser predictores significativos de la evolución. El valor predictivo del CCI y la RSI no se debe a efectos farmacológicos iniciales, sino a factores de tratamiento no específicos.

Keywords

respuesta inicialantidepresivospredictiónevolucióndepresión
Type
Artículo Original
Information
European Psychiatry (Ed. Española) , Volume 4 , Issue 6 , September 1997 , pp. 382 - 388
Copyright
Copyright © European Psychiatric Association 1997

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Footnotes

Priebe S, Bröker M. Initial response to active drug and placebo predicts outcome of antidepressant treatment. Eur Psychiatry 1997; 12: 28-33.

References

Bibliografia

American Psychiatric Association. Diagnostic and Statistical Manual o f Mental Disorders, 3rd edn Revised, DSM-III-R. Washington, DC: American Psychiatric Association, 1987.Google Scholar
Bartko, G, Herczeg, I, Bekesy, M. Predicting outcome of neuroleptic treatment on the basis of subjective response and early clinical improvement. J Clin Psychiatry 1987; 48: 363-5.Google ScholarPubMed
Bielski, RJ, Friedel, RO. Prediction of tricyclic antidepressant response: A critical review. Arch Gen Psychiatry 1976; 33: 1479-89.CrossRefGoogle ScholarPubMed
Brody, H. Placebos and the Philosophy o f Medicine. Chicago: The University of Chicago Press, 1980.Google Scholar
Bröker, M, Rohricht, F, Priebe, S.Initial assessment of hospital treatment by patients with paranoid schizophrenia: A predictor of outcome. Psychiatr Res 1995; 58: 77-81.CrossRefGoogle ScholarPubMed
Coryell, W, Coppen, A, Zeigler, VE, Biggs, JT. Early improvement as a predictor of response to amitriptiline and nortriptyline: a comparison of 2 patient samples. Psychol Med 1982; 12: 135-9.CrossRefGoogle Scholar
Fink, EB, Braden, W, Qualls, CB. Predicting pharmacotherapy outcome by subjective response. J Clin Psychiatry 1982; 43: 272-5.Google ScholarPubMed
Goodwin, FK. Predictors of antidepresant response. Bull Meninger Clin 1993; 57: 146-60.Google Scholar
Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.CrossRefGoogle ScholarPubMed
Joyce, CRB. Non-specific aspects of treatment from the point of view of a clinical pharmacologist. In: Shepherd, M, Sartorius, N, eds. Non-Specific Aspects o f Treatment. Toronto: Huber, 1989: 57-94.Google Scholar
Joyce, PR, Paykel, ES. Predictors of drug response in depression. Arch Gen Psychiatry 1989; 46: 89-99.CrossRefGoogle ScholarPubMed
Katz, MM, Koslow, SH, Maas, JW et al. The timing, specificity and clinical prediction of tricyclic drug effects in depression. Psychol Med 1987; 17: 297-309.CrossRefGoogle ScholarPubMed
Klerman, GL, Cole, JO. Clinical pharmacology of imipramine and related antidepressant compounds. Pharmacol Rev 1965; 17: 101-41.Google ScholarPubMed
Kocsis, JH. New issues in the prediction of antidepressant response. Psychopharmacol Bull 1990; 16: 49-53.Google Scholar
May, PRA, Goldberg, SC.Prediction of schizophrenic patient's response to pharmacotherapy. In: Lipton, MA, DiMascio, A, Killam, KF, eds. Psychopharmacology: A Generation o f Progress. New York: Raven: 1978: 1139-53.Google Scholar
May, PRA, Van Putten, T, Yale, C et al. Predicting individual responses to drug treatment in schizophrenia: A test dose model. J Nerv Ment Dis 1976; 162: 177-83.CrossRefGoogle ScholarPubMed
May, PRA, Van Putten, T, Yale, C.Predicting outcome of antipsychotic drug treatment from early response. Am J Psychiatry 1980; 137: 1088-9.Google ScholarPubMed
May, PRA, Van Putten, T, Jenden, DJ, Yale, C, Dixon, WJ, Goldstein, MJ. Prognosis in schizophrenia: Individual differences in psychological response to a test dose of antipsychotic drug and their relationship to blood and saliva levels and treatment outcome. Compr Psychiatry 1981; 22: 147-52.CrossRefGoogle ScholarPubMed
Morris, JB, Beck, AT. The efficacy of antidepressant drugs. A review of research (1958-1972). Arch Gen Psychiatry 1974; 30: 667-74.CrossRefGoogle ScholarPubMed
Nagayama, H, Nagano, K, Ikezaki, A, Tashiro, T. Prediction of efficacy of antidepresant by 1-week test therapy in depression. J Ajfect Dis 1991; 23: 213-6.CrossRefGoogle Scholar
Nedopil, N, Ruther, E. Initial improvement as predictor of outcome of neuroleptic treatment. Pharmacopsychiat 1981; 14: 205-7.CrossRefGoogle ScholarPubMed
Nedopil, N, Pflieger, R, Ruther, E. The prediction of acute response, remission and general outcome of neuroleptic treatment in acute schizophrenic patients. Pharmacopsychiat 1983; 16: 201-5.CrossRefGoogle ScholarPubMed
Priebe, S. Early subjective reactions predicting the outcome of hospital treatment in depressive patients. Acta Psychiatr Scand 1987; 76: 134-138.CrossRefGoogle ScholarPubMed
Priebe, S.Die Bedeutung der Patientenmeinung. Initiale Bewertung und Verlauf psychiatrischer Therapie. Gottingen: Hogrefe, 1992.Google Scholar
Priebe, S, Gruyters, T. Patient's and caregivers’ initial assessments of day hospital treatment and course of symptoms. Compr Psychiatry 1994; 35: 234-8.CrossRefGoogle Scholar
Priebe, S, Gruyters, T. The importance of the first three days: Predictors of treatment outcome in depressed inpatients. Br J Clin Psychol 1995; 34: 229-36.CrossRefGoogle Scholar
Rickels, K.Non-specific factor in drug therapy of neurotic patients. In: Rickels, K, ed Non-Specific Factors in Drug Therapy. Springfield: Thomas, 1968: 3-26.Google Scholar
Rothschild, R, Quitkin, FM. Review of the use of pattern analysis to differentiate true and drug and placebo responses. Psychother Psychosom 1992; 58: 170-7.CrossRefGoogle ScholarPubMed
Singh, MM. Dysphoric response to neuroleptic treatment in schizophrenia and its prognostic significance. Dis Nerv Syst 1976; 37: 191-6.Google ScholarPubMed
Singh, MM, Kay, SR. Dysphoric response to neuroleptic treatment in schizophrenia: Its relationship to autonomic arousal and prognosis. Biol Psychiatry 1979; 14: 277-94.Google ScholarPubMed
Singh, MM, Smith, JM. Kinetics and dynamics of response to haloperidol in acute schizophrenia - a longitudinal study of the therapeutic process. Compr Psyciatry 1973; 14: 393-414.CrossRefGoogle ScholarPubMed
Van Putten, T, May, PRA. Subjective response as a predictor of outcome in pharmacotherapy. Arch Gen Psyciatry 1978; 35: 477-80.CrossRefGoogle ScholarPubMed
Van Putten, T, May, PRA, Jenden, DJ, Cho, AK, Jale, C.Plasma and saliva levels of chlorpromazine and subjective response. Am J Psychiatry 1980a; 137: 1241-2.Google Scholar
Van Putten, T, May, PRA, Marder, SR.Subjective responses to thiotixine and chlorpromazine. Psychopharmacol Bull 1980b; 16: 36-8.Google Scholar
Van Putten, T, May, PRA, Marder, SR, Wittman, LA. Subjective response to antipsychotic drugs. Arch Gen Psychiatry 1981; 38: 187-90.CrossRefGoogle ScholarPubMed
Woggon, B, Baumann, U. Multimethodological approach in psychiatric predictor research. Pharmacopsychiat 1983; 16: 175-78.CrossRefGoogle ScholarPubMed
Woggon, B.Unsolved problems in the pharmacotherapy of depression. In: Casey, DE, Christensen, AV, eds. Psychopharmacology: Current Trends. Psychopharmacology Series 5. Berlin: Springer, 1988: 159-65.CrossRefGoogle Scholar