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Concentraciones elevadas de lipoproteína(a) en plasma en pacientes psiquiátricos: una posible contribución al aumento del riesgo vascular

Published online by Cambridge University Press:  12 May 2020

Enzo Emanuele
Affiliation:
Laboratorio de Medicina Nuclear, Clinica Medica 2, IRCCS Policlínico San Mateo, Universidad de Pavía, Piazzale Golgi, 2, 27100Pavía, Italia
Maria V. Carlin
Affiliation:
Servicio Psiquiátrico de Diagnóstico y Cura, IRCCS Policlínico San Mateo, ASL, Universidad de Pavía, Pavía, Italia
Angela D’Angelo
Affiliation:
Laboratorio de Medicina Nuclear, Clinica Medica 2, IRCCS Policlínico San Mateo, Universidad de Pavía, Piazzale Golgi, 2, 27100Pavía, Italia
Emmanouil Peros
Affiliation:
Laboratorio de Medicina Nuclear, Clinica Medica 2, IRCCS Policlínico San Mateo, Universidad de Pavía, Piazzale Golgi, 2, 27100Pavía, Italia
Francesco Barale
Affiliation:
Servicio Psiquiátrico de Diagnóstico y Cura, IRCCS Policlínico San Mateo, ASL, Universidad de Pavía, Pavía, Italia
Diego Geroldi
Affiliation:
Laboratorio de Medicina Nuclear, Clinica Medica 2, IRCCS Policlínico San Mateo, Universidad de Pavía, Piazzale Golgi, 2, 27100Pavía, Italia
Pierluigi Politi
Affiliation:
Servicio Psiquiátrico de Diagnóstico y Cura, IRCCS Policlínico San Mateo, ASL, Universidad de Pavía, Pavía, Italia
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Resumen

Se ha comunicado un aumento de la incidencia de acontecimientos cardiovasculares adversos en los pacientes psiquiátricos, pero los mecanismos exactos que subyacen a esta asociación no están claros todavía. La elevación de la concentración de lipoproteána(a) [Lp(a)] en plasma es un factor de riesgo independiente para la enfermedad aterotrombótica en la población general. Para estudiar las implicaciones de la Lp(a) en los pacientes psiquiátricos, medimos las concentraciones de Lp(a) en plasma en 74 pacientes con trastornos psiquiátricos (39 con esquizofrenia, 10 con depresión mayor, 13 con trastorno bipolar y 12 con trastorno de la personalidad) y 74 controles sanos. Las concentraciones de Lp(a) de los grupos de pacientes con esquizofrenia, depresión mayor y trastorno bipolar fueron significativamente más altas que las del grupo de control. La mediana del valor de Lp(a) de estos grupos diagnósticos fue comparable a la comunicada en pacientes con acontecimientos aterotrombóticos anteriores. Por otra parte, no se encontraron diferencias entre el grupo con trastorno de la personalidad y los controles. Nuestros hallazgos indican que la elevación de Lp(a) en plasma puede contribuir a un aumento del riesgo cardiovascular en algunos pacientes con trastornos psiquiátricos.

Type
Original
Copyright
Copyright © European Psychiatric Association 2006

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Concentraciones elevadas de lipoproteína(a) en plasma en pacientes psiquiátricos: una posible contribución al aumento del riesgo vascular
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