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A pharmacokinetic-dynamic explanation of the rapid onset–offset of rapacuronium

Published online by Cambridge University Press:  16 August 2006

J. H. Proost  and
P. M. C. Wright
J. H. Proost
Affiliation:
Research Group for Experimental Anaesthesiology and Clinical Pharmacology, Department of Anaesthesiology, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
P. M. C. Wright
Affiliation:
Academic Department of Anaesthesia, University of Newcastle upon Tyne, UK
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Abstract

The rapid onset and offset of rapacuronium can be explained from its pharmacokinetic and pharmacodynamic characteristics. A unique property of rapacuronium is its high value for ke0, indicating a rapid access to the receptor site. The reason for this high ke0 may be related to the low intrinsic potency of rapacuronium, but this is not yet fully clarified.

Keywords

nuromuscular blocking agentsrapacuroniumpharmacodynamicsonsetoffsetpharmacokineticsclearancerate constants
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 18 , Issue S23 , November 2001 , pp. 83 - 89
Copyright
2001 European Society of Anaesthesiology

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