Hostname: page-component-8448b6f56d-c47g7 Total loading time: 0 Render date: 2024-04-25T04:51:22.632Z Has data issue: false hasContentIssue false

Evaluation of standard haemodynamic tests of autonomic function and HbA1c as predictors of delayed gastric emptying in patients with type 1 diabetes mellitus

Published online by Cambridge University Press:  16 August 2006

A. Lydon
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Cork, Ireland
C. Murray
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Cork, Ireland
T. Cooke
Affiliation:
Department of Biochemistry, Cork University Hospital and University College Cork, Cork, Ireland
P. F. Duggan
Affiliation:
Department of Biochemistry, Cork University Hospital and University College Cork, Cork, Ireland
D. O'Halloran
Affiliation:
Department of Medicine, Cork University Hospital and University College Cork, Cork, Ireland
G. D. Shorten
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Cork, Ireland
Get access

Abstract

We examined the relation between chronic glycaemic control (using glycosylated haemoglobin), haemodynamic autonomic function and rate of gastric emptying in 16 patients with type 1 diabetes mellitus. Gastric emptying was measured using a paracetamol absorption technique. Parameters of gastric emptying include area under the plasma paracetamol concentration time curve. Patients were classified as diabetic autonomic neuropathy positive or negative using five standardized haemodynamic reflex tests. Area under the plasma paracetamol concentration time curve in the neuropathy positive (10.36 (4.5) mmol−1 min) and negative (9.84 (3.0) mmol−1 min) groups were similar (P=0.42) using unpaired Student's t-tests. Glycosylated haemoglobin concentration and area under the plasma paracetamol concentration time curve (n=16) demonstrated a Pearson's correlation co-efficient of 0.24. Neither tests of haemodynamic autonomic function, nor concentration of glycosylated haemoglobin, are predictive of diabetic gastroparesis.

Type
Original Article
Copyright
2000 European Society of Anaesthesiology

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)