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Epoetin alfa facilitates presurgical autologous blood donation in non-anaemic patients scheduled for orthopaedic or cardiovascular surgery

Published online by Cambridge University Press:  16 August 2006

J. P. Cazenave
Affiliation:
Etablissement de Transfusion Sanguine, B. P. No. 36, 10 rue Spielmann, F-67065 Strasbourg, France
C. Irrmann
Affiliation:
Hôpital Stéphanie, F-67100 Strasbourg-Neudorf, France
C. Waller
Affiliation:
Etablissement de Transfusion Sanguine, B. P. No. 36, 10 rue Spielmann, F-67065 Strasbourg, France
D. Sondag
Affiliation:
Hôpital Stéphanie, F-67100 Strasbourg-Neudorf, France
E. Baudoux
Affiliation:
Centre de Transfusion CHU Liège, Sart Tilman, B-4000 Liege, Belgium
B. Genetet
Affiliation:
Centre Régional de Transfusion Sanguine, Rue Pierre Jean Gineste, F-35000 Rennes, France
M. C. Laxenaire
Affiliation:
Centre Hospitalier Régional Universitaire, 29 Avenue de Maréchal de Lattre de Tassigny, F-54037, Nancy, France
E. Dupont
Affiliation:
Department d'Immunologie-Hématologie-Transfusion, Clinique Universitaire de Bruxelles, B-1070 Bruxelles, Belgium
E. Sundal
Affiliation:
R W Johnson Pharmaceutical Research Institute, Grindelstrasse 40, CH-8303, Bassersdorf, Switzerland
R. Obrist
Affiliation:
R W Johnson Pharmaceutical Research Institute, Grindelstrasse 40, CH-8303, Bassersdorf, Switzerland
H. Stocker
Affiliation:
R W Johnson Pharmaceutical Research Institute, Grindelstrasse 40, CH-8303, Bassersdorf, Switzerland
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Abstract

Patients expected to need at least three units of blood for their elective cardiovascular or orthopaedic surgery, were allocated randomly to receive intravenous (i.v.) Epoetin alfa 600 IU kg−1 (n = 27), 300 IU kg−1 (n = 30) or placebo (n = 23), on days 1, 4 and 7. Provided haemoglobin ≥ 11 g dL−1, one unit of blood was collected on days 1, 4, 7, 11 and 14. Iron supplementation was given throughout the study. Surgery was scheduled between days 18 and 21. Significantly more patients treated with Epoetin alfa (100% for 600 IU kg −1 ; 97% for 300 IU kg−1) were able to donate ≥ 4 units of blood compared with placebo (78%) (P = 0.011 and P = 0.032). No significant differences were seen in total patient exposure to homologous blood (7.4%, 3.3% and 17.4%, respectively). Mean red cell volume donated (P = 0.005 for 600 IU kg−1 ; P = 0.158 for 300 IU kg−1 both vs. placebo) and production (P < 0.001 and P = 0.012, respectively) were dose related. Twenty-four patients became iron deficient. No differences in the incidence of adverse events were seen between the groups.

Type
Original Article
Copyright
1997 European Society of Anaesthesiology

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