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Effects of dexmedetomidine infusion in patients undergoing functional endoscopic sinus surgery under local anaesthesia

Published online by Cambridge University Press:  01 January 2008

S. Goksu*
Affiliation:
University of Gaziantep, Faculty of Medicine, Department of Anaesthesiology and Reanimation, Gaziantep, Turkey
H. Arik
Affiliation:
University of Gaziantep, Faculty of Medicine, Department of Anaesthesiology and Reanimation, Gaziantep, Turkey
S. Demiryurek
Affiliation:
Gazi University, Faculty of Medicine, Department of Physiology, Ankara, Turkey
S. Mumbuc
Affiliation:
University of Gaziantep, Faculty of Medicine, Department of Otolaryngology and Head and Neck Surgery, Gaziantep, Turkey
U. Oner
Affiliation:
University of Gaziantep, Faculty of Medicine, Department of Anaesthesiology and Reanimation, Gaziantep, Turkey
A. T. Demiryurek
Affiliation:
University of Gaziantep, Faculty of Medicine, Department of Pharmacology, Gaziantep, Turkey
*
Correspondence to: Sitki Goksu, Department of Anaesthesiology and Reanimation, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey. E-mail: sitkigoksu@yahoo.com; Tel/Fax: 90 342 360 22 44
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Summary

Background and objectives

Functional endoscopic sinus surgery can be performed under either local or general anaesthesia. The objective of this study was to investigate the haemodynamic effects of perioperatively administered dexmedetomidine, a new generation α-2-agonist, in patients for functional endoscopic sinus surgery.

Methods

Sixty-two patients who were planned to undergo functional endoscopic sinus surgery under local anaesthesia were included in the study. Following meperidine premedication, both groups were monitored in a standard manner with electrocardiogram, non-invasive blood pressure and percentages of peripheral saturation of oxygen. Saline intravenous infusion was started in the placebo group, and dexmedetomidine bolus intravenous infusion (an initial loading dose of 1 μg kg−1 given for a 10-min period followed by 0.7 μg kg−1 h−1) was administered to the treatment group. Maintenance dose infusion was stopped 15 min before the end of the surgical procedure.

Results

Systolic, diastolic and mean arterial pressures, and heart rate markedly decreased in the dexmedetomidine group. However, dexmedetomidine had no effect on serum nitric oxide levels, measured by a nitric oxide/ozone chemiluminescence method. No significant difference was found in oxygen saturation levels of the two groups. Postoperative nausea and vomiting rates were significantly lower in the dexmedetomidine group. No adverse effects were observed with this α-2-agonist. Dexmedetomidine provided appropriate levels of sedation.

Conclusion

These results suggest that dexmedetomidine provides analgesia, adequate sedation and surgical comfort without adverse effects for patients undergoing functional endoscopic sinus surgery under local anaesthesia.

Type
Original Article
Copyright
Copyright © European Society of Anaesthesiology 2007

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