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Neurotic depression as the missing link: old wine with a new twist on anxiety and major depressive disorder

Published online by Cambridge University Press:  11 May 2015

A. A. Nierenberg*
Affiliation:
Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston MA
K. K. Ellard
Affiliation:
Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston MA
*
Address for correspondence: Andrew A. Nierenberg, MD, Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Suite 580, 50 Staniford Street, Boston MA 02114. (Email: anierenberg@mgh.harvard.edu)

Abstract

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Type
Commentaries to Special Article
Copyright
Copyright © Cambridge University Press 2015 

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References

Akers, KG, Martinez-Canabal, A, Restivo, L, Yiu, AP, De Cristofaro, A, Hsiang, H-LL, Wheeler, AL, Guskjolen, A, Niibori, Y, Shoji, H (2014). Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science 344, 598602.Google Scholar
Barlow, DH, Ellard, KK, Sauer-Zavala, S, Bullis, JR, Carl, JR (2014 a). The origins of neuroticism. Perspectives on Psychological Science 9, 481496.Google Scholar
Barlow, DH, Sauer-Zavala, S, Carl, JR, Bullis, JR, Ellard, KK (2014 b). The nature, diagnosis, and treatment of neuroticism back to the future. Clinical Psychological Science 2, 344365.Google Scholar
Clelland, CD, Choi, M, Romberg, C, Clemenson, GD, Fragniere, A, Tyers, P, Jessberger, S, Saksida, LM, Barker, RA, Gage, FH (2009). A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 325, 210213.Google Scholar
Ellard, KK, Fairholme, CP, Boisseau, CL, Farchione, TJ, Barlow, DH (2010). Unified protocol for the transdiagnostic treatment of emotional disorders: protocol development and initial outcome data. Cognitive and Behavioral Practice 17, 88101.Google Scholar
Farchione, TJ, Fairholme, CP, Ellard, KK, Boisseau, CL, Thompson-Hollands, J, Carl, JR, Gallagher, MW, Barlow, DH (2012). Unified protocol for transdiagnostic treatment of emotional disorders: a randomized controlled trial. Behavior Therapy 43, 666678.Google Scholar
Harmer, CJ, Cowen, PJ (2013). ‘It's the way that you look at it’ – a cognitive neuropsychological account of SSRI action in depression. Philosophical Transactions of the Royal Society B: Biological Sciences 368, 20120407.Google Scholar
Holtzheimer, PE, Mayberg, HS (2011). Stuck in a rut: rethinking depression and its treatment. Trends in Neurosciences 34, 19.Google Scholar
Malberg, JE, Eisch, AJ, Nestler, EJ, Duman, RS (2000). Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. The Journal of Neuroscience 20, 91049110.Google Scholar
McCabe, C, Mishor, Z (2011). Antidepressant medications reduce subcortical cortical resting-state functional connectivity in healthy volunteers. NeuroImage 57, 13171323.Google Scholar
Milad, MR, Rosenbaum, BL, Simon, NM (2014). Neuroscience of fear extinction: implications for assessment and treatment of fear-based and anxiety related disorders. Behaviour Research and Therapy 62, 1723.Google Scholar
Pessoa, L (2008). On the relationship between emotion and cognition. Nature Reviews Neuroscience 9, 148158.Google Scholar
Sahay, A, Scobie, KN, Hill, AS, O'Carroll, CM, Kheirbek, MA, Burghardt, NS, Fenton, AA, Dranovsky, A, Hen, R (2011). Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472, 466470.Google Scholar
Sen, S, Duman, R, Sanacora, G (2008). Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biological Ppsychiatry 64, 527532.Google Scholar
Soskin, DP, Carl, JR, Alpert, J, Fava, M (2012). Antidepressant effects on emotional temperament: toward a biobehavioral research paradigm for major depressive disorder. CNS Neuroscience & Therapeutics, 18, 441451.Google Scholar
Yassa, MA, Stark, CEL (2011). Pattern separation in the hippocampus. Trends in Neurosciences 34, 515525.Google Scholar