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Depression and treatment nonadherence in type 2 diabetes: Assessment issues and an integrative treatment approach

Published online by Cambridge University Press:  11 April 2011

Jeffrey S. Gonzalez  and
Sabrina A. Esbitt
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Abstract

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Research has found that depression is more common among individuals with diabetes and is associated with worse diabetes outcomes including treatment nonadherence, worse glycemic control, higher risk of diabetes complications, greater functional impairment, and increased risk of mortality. These patterns of association have led to an increase in research investigating the relationship between diabetes and depression. There remain important questions about the relationship between depression and diabetes and an unmet need for treatment approaches that are successful in ameliorating depression and improving diabetes outcomes. The current commentary discusses several conceptual issues related to the measurement of depression in diabetes, argues for the importance of health behavior and treatment adherence in approaching the problem of depression in diabetes, and provides an example of a treatment approach that incorporates the treatment of depression with strategies aimed at improving treatment adherence in order to maximize effects on diabetes outcomes.

Type
Editorials
Information
Epidemiology and Psychiatric Sciences , Volume 19 , Issue 2 , June 2010 , pp. 110 - 115
Copyright
Copyright © Cambridge University Press 2010

References

Ali, S., Stone, M., Peters, J., Davies, M. & Khunti, K. (2006). The prevalence of co-morbid depression in adults with type 2 diabetes: a systematic review and meta-analysis. Diabetic Medicine 23, 1165–1173.CrossRefGoogle ScholarPubMed
American Diabetes Association(2009). Standards of medical care in diabetes. Diabetes Care, 32, S13–61.CrossRefGoogle Scholar
American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders (4th edition, text revision). American Psychiatric Association: Washington DC.Google Scholar
Anderson, R., Freedland, K., Clouse, R. & Lustman, P. (2001). The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care 24,1069–1078.CrossRefGoogle ScholarPubMed
Black, S., Markides, K. & Ray, L. (2003). Depression predicts increased incidence of adverse health outcomes in older Mexican Americans with type 2 diabetes. Diabetes Care 26, 2822–2828.CrossRefGoogle ScholarPubMed
Chiu, C-J., Wray, L., Beverly, E. & Dominic, O. (in press). The role of health behaviors in mediating the relationship between depressive symptoms and glycemic control in type 2 diabetes: a structural equation modeling approach. Social Psychiatry and Psychiatric Epidemiology.Google Scholar
Ciechanowski, P., Katon, W. & Russo, J. (2005). The association of depression and perceptions of interpersonal relationships in patients with diabetes. Journal of Psychosomatic Research 58, 139–144.CrossRefGoogle ScholarPubMed
de Groot, M., Anderson, R., Freedland, K., Clouse, R. & Lustman, P. (2001). Association of depression and diabetes complications: a meta-analysis. Psychosomatic Medicine 63, 619–630.CrossRefGoogle ScholarPubMed
Diabetes Control and Complications Trial Research Group. (2003). The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. New England Journal of Medicine 329, 977–986.Google Scholar
DiMatteo, M. (2004). Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. Medical Care 42, 200–209.CrossRefGoogle ScholarPubMed
DiMatteo, M., Lepper, H. & Croghan, T. (2000). Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Archives of Internal Medicine 160, 2101–2107.CrossRefGoogle ScholarPubMed
Eaton, W. (2002). Epidemiologic evidence on the comorbidity of depression and diabetes. Journal of Psychosomatic Research 53, 903–906.CrossRefGoogle ScholarPubMed
Egede, L. (2004). Effects of depression on work loss and disability bed days in individuals with diabetes. Diabetes Care 27, 1751–1753.CrossRefGoogle ScholarPubMed
Fisher, L., Skaff, M., Mullan, J., Arean, P., Mohr, D., Masharani, U., Glasgow, R. & Laurencin, G. (2007 b). Clinical depression versus distress among patients with type 2 diabetes: not just a question of semantics. Diabetes Care 30, 542–548.CrossRefGoogle Scholar
Fisher, L., Skaff, M., Mullan, J., Arean, P., Glasgow, R. & Masharani, U. (2008). A longitudinal study of affective and anxiety disorders, depressive affect and diabetes distress in adults with type 2 diabetes. Diabetic Medicine 25, 1096–1101.CrossRefGoogle ScholarPubMed
Fisher, L., Mullan, J., Arean, P., Glasgow, R., Hessler, D. & Masharani, U. (2010). Diabetes distress but not clinical depression or depressive symptoms is associated with glycemic control in both cross-sectional and longitudinal analyses. Diabetes Care 33, 23–28.CrossRefGoogle ScholarPubMed
Golden, S. (2007). A review of the evidence for a neuroendocrine link between stress, depression and diabetes mellitus. Current Diabetes Reviews 3, 252–259.CrossRefGoogle ScholarPubMed
Gonzalez, J., Safren, S., Cagliero, E., Wexler, D., Delahanty, L., Wittenberg, E., Blais, M., Meigs, J. & Grant, R. (2007). Depression, self-care, and medication adherence in type 2 diabetes: relationships across the full range of symptom severity. Diabetes Care 30, 2222–2227.CrossRefGoogle ScholarPubMed
Gonzalez, J., Delahanty, L., Safren, S., Meigs, J. & Grant, R. (2008 a). Differentiating symptoms of depression from diabetes-specific distress: relationships with self-care in type 2 diabetes. Diabetologia 51, 1822–1825.CrossRefGoogle ScholarPubMed
Gonzalez, J., Peyrot, M., McCarl, L., Collins, E., Serpa, L., Mimiaga, M. & Safren, S. (2008 b). Depression and diabetes treatment nonadherence: a meta-analysis. Diabetes Care 31, 2398–2403.CrossRefGoogle ScholarPubMed
Gonzalez, J., McCarl, L., Wexler, D., Cagliero, E., Delahanty, L., Soper, T.,Goldman, V.,, Knauz, R. & Safren, S. (in press). Cognitive behavioral therapy for adherence and depression (CBT-AD) in type 2 diabetes: an open pilot study. Journal of Cognitive Psychotherapy.Google Scholar
Katon, W. (2003). Clinical and health services relationships between major depression, depressive symptoms, and general medical illness. Biological Psychiatry 54, 216–226.CrossRefGoogle ScholarPubMed
Katon, W. & Ciechanowski, P. (2002). Impact of major depression on chronic medical illness. Journal of Psychosomatic Research 53, 859–863.CrossRefGoogle ScholarPubMed
Katon, W., Rutter, C., Simon, G., Lin, E., Ludman, E., Ciechanowski, P., Kinder, L., Young, B. & Von Korff, M. (2005). The association of comorbid depression with mortality in patients with type 2 diabetes. Diabetes Care 28, 2668–2672.CrossRefGoogle ScholarPubMed
Katon, W., Fan, M., Unützer, J., Taylor, J., Pincus, H. & Schoenbaum, M. (2008). Depression and diabetes: a potentially lethal combination. Journal of General Internal Medicine 23, 1571–1575.CrossRefGoogle ScholarPubMed
Lin, E., Katon, W., Rutter, C., Simon, G., Ludman, E., Von Korff, M., Young, B., Oliver, M., Ciechanowski, P., Kinder, L. & Walker, E. (2009). Effects of enhanced depression treatment on diabetes selfcare. Annals of Family Medicine 4, 46–53.CrossRefGoogle Scholar
Lustman, P., Griffith, L., Freedland, K. & Clouse, R. (1997). The course of major depression in diabetes. General Hospital Psychiatry 19, 138–143.CrossRefGoogle ScholarPubMed
Lustman, P., Griffith, L., Freedland, K., Kissel, S. & Clouse, R. (1998). Cognitive behavior therapy for depression in type 2 diabetes mellitus. A randomized, controlled trial. Annals of Internal Medicine 129, 613–621.CrossRefGoogle ScholarPubMed
Lustman, P., Anderson, R., Freedland, K., de Groot, M., Carney, R. & Clouse, R. (2000). Depression and poor glycemic control: a metaanalytic review of the literature. Diabetes Care 23, 934–942.CrossRefGoogle ScholarPubMed
Lustman, P., Clouse, R., Ciechanowski, P., Hirsch, I. & Freedland, K. (2005). Depression-related hyperglycemia in type 1 diabetes: a mediational approach. Psychosomatic Medicine 67, 195–199.CrossRefGoogle ScholarPubMed
Lustman, P., Williams, M., Sayuk, G., Nix, B. & Clouse, R. (2007). Factors influencing glycemic control in type 2 diabetes during acute- and maintenance-phase treatment of major depressive disorder with bupropion. Diabetes Care 30, 459–466.CrossRefGoogle ScholarPubMed
Markowitz, S., Gonzalez, J, Wilkinson, J. & Safren, S. (in press). Treating depression in diabetes: emerging findings. Psychosomatics.Google Scholar
McGrady, M., Laffel, L., Drotar, D., Repaske, D. & Hood, K. (2009). Depressive symptoms and glycemic control in adolescents with type 1 diabetes: mediational role of blood glucose monitoring. Diabetes Care 32, 804–806.CrossRefGoogle ScholarPubMed
Moscicki, E. (2001). Epidemiology of completed and attempted suicide: toward a framework for prevention. Clinical Neuroscience Research 1, 310–23.CrossRefGoogle Scholar
Musselman, D., Betan, E., Larsen, H. & Phillips, L. (2003). Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment. Biological Psychiatry 54, 317–329.CrossRefGoogle ScholarPubMed
Norris, S., Zhang, X., Avenell, A., Gregg, E., Bowman, B., Serdula, M., Brown, T., Schmid, C. & Lau, J. (2004). Long-term effectiveness of lifestyle and behavioral weight loss interventions in adults with type 2 diabetes: a meta-analysis. American Journal of Medicine 117, 762–774.CrossRefGoogle ScholarPubMed
Petrak, F, Herpertz, S, Albus, C, Kulzer, B, Kruse, J. (2005). Psychosocial factors and diabetes mellitus: evidence-based treatment guidelines. Current Diabetes Reviews, 1, 255–270.CrossRefGoogle ScholarPubMed
Rubin, R. (2005). Adherence to pharmacologic therapy in patients with type 2 diabetes mellitus. In Pharmacologic Treatment of Type 2 Diabetes Mellitus (ed. D., Klonoff). American Journal of Medicine, Suppl. 5, vol.118, pp. 27–34.CrossRefGoogle Scholar
Safren, S., Gonzalez, J. & Soroudi, N. (2008 a). CBT for Depression and Adherence in Individuals with Chronic Illness: Client Workbook (Treatments That Work). Oxford University Press: New York.Google Scholar
Safren, S., Gonzalez, J. & Soroudi, N. (2008 b). CBT for Depression and Adherence in Individuals with Chronic Illness: Therapist Guide (Treatments That Work). Oxford University Press: New York.Google Scholar
Safren, S A, O'Cleirigh, C, Tan, J Y, Raminani, S R, Reilly, L, Otto, M W, Mayer, K H. (2009). A randomized controlled trial of cognitive behaviural therapy for adherence and depression (CBT-AD) in HIVinfected individuals. Health Psychology, 28, 1–10.CrossRefGoogle Scholar
Shaw, J., Sicree, R. & Zimmet, P. (in press). Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice.CrossRefGoogle Scholar
Strine, T., Mokdad, A., Dube, S., Balluz, L., Gonzalez, O., Berry, J., Manderscheid, R. & Kroenke, K. (2008). The association of depression and anxiety with obesity and unhealthy behaviors among communitydwelling US adults. General Hospital Psychiatry 30, 127–137.CrossRefGoogle ScholarPubMed
Van Tilburg, M., McCaskill, C., Lane, J., Edwards, C., Bethel, A., Feinglos, M. & Surwit, R. (2001). Depressed mood is a factor in glycemic control in type 1 diabetes. Psychosomatic Medicine 63, 551–555.CrossRefGoogle ScholarPubMed
Von Korff, M., Katon, W., Lin, E., Simon, G., Ciechanowski, P., Ludman, E., Oliver, M., Rutter, C. & Young, B. (2005). Work disability among individuals with diabetes. Diabetes Care 28, 1326–1332.CrossRefGoogle ScholarPubMed
Willis, T. (1971). Diabetes: A Medical Odyssey. Tuckahoe: New York.Google Scholar
Zhang, X., Norris, S., Gregg, E., Cheng, Y.Beckles, G. & Kahn, H. (2005). Depressive symptoms and mortality among persons with and without diabetes. American Journal of Epidemiology 161, 652–660.CrossRefGoogle ScholarPubMed