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Virulence of urinary and faecal Escherichia coli in relation to serotype, haemolysis and haemagglutination

Published online by Cambridge University Press:  25 March 2010

J. F. van den Bosch ,
P. Postma ,
P. A. R. Koopman ,
J. de Graaff ,
D. M. MacLaren ,
D. G. van Brenk  and
P. A. M. Guinée
J. F. van den Bosch
Affiliation:
Departments of Medical Microbiology, Oral Microbiology and Medical Statistics, Free University, Amsterdam, The Netherlands
P. Postma
Affiliation:
Departments of Medical Microbiology, Oral Microbiology and Medical Statistics, Free University, Amsterdam, The Netherlands
P. A. R. Koopman
Affiliation:
Departments of Medical Microbiology, Oral Microbiology and Medical Statistics, Free University, Amsterdam, The Netherlands
J. de Graaff
Affiliation:
Departments of Medical Microbiology, Oral Microbiology and Medical Statistics, Free University, Amsterdam, The Netherlands
D. M. MacLaren
Affiliation:
Departments of Medical Microbiology, Oral Microbiology and Medical Statistics, Free University, Amsterdam, The Netherlands
D. G. van Brenk
Affiliation:
National Institute of Public Health, Bilthoven, The Netherlands
P. A. M. Guinée
Affiliation:
Departments of Medical Microbiology, Oral Microbiology and Medical Statistics, Free University, Amsterdam, The Netherlands
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The virulence of faecal and urinary Escherichia coli strains was studied in relation to serotype, haemolysin production and haemagglutination pattern. By means of an experimental mouse model E. coli strains can be divided into avirulent (I), mouse nephropathogenic (II), and generally virulent (III) strains. Virulent group II and group III strains were more often haemolytic and haemagglutinating than avirulent group I strains. Presence of K antigen could not be associated with virulence. Discriminant analysis for qualitative variables revealed that no combination of the investigated properties contributed more to a strain's virulence level than did one single property. It is concluded that other virulence factors, apart from haemolysin production in group II strains and haemagglutinins in group III strains, must be involved in the determination of a strain's virulence level.

All O2, O6 and O18ac strains tested were virulent, and by far the most O75 strains were avirulent, whereas other O groups were more variable with regard to virulence. Pyelonephritis strains were more often mannose-resistant haemagglutinating than faecal and other urinary isolates, indicating that mannoseresistant adhesins may be important in the pathogenesis of pyelonephritis.

Type
Research Article
Information
Journal of Hygiene , Volume 88 , Issue 3 , June 1982 , pp. 567 - 577
Copyright
Copyright © Cambridge University Press 1982

References

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