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Vaccination of guinea-pigs and human beings against leptospiral infections

Published online by Cambridge University Press:  15 May 2009

J. Smith
J. Smith
Affiliation:
From the City Hospital Laboratory, Aberdeen
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1. Guinea-pig vaccination experiments have shown that these animals can be rendered completely immune from infection with virulent strains of L. icterohaemorrhagiae when they are treated with non-virulent living vaccines, or formalinized, heat-killed, phenolized, and dettolized suspensions of virulent cultures.

2. Vaccination with homologous strains of L. icterohaemorrliagiae produced better immunity than when heterologous strains such as L. hebdomadis or L. icterohaemorrhagiae Rachmat are employed.

3. Immune bodies are demonstrable in the serum of guinea-pigs vaccinated with L. icterohaemorrhagiae Weil, and a lytic titre of 1/6 appears to indicate that sufficient protective antibodies are present.

4. Following upon vaccination and inoculation with virulent cultures, carrier conditions have developed in animals treated with chemically killed vaccines of L. icterohaemorrhagiae Weil and with living non-virulent suspensions of the heterologous strain L. hebdomadis and L. icterohaemorrhagiae Rachmat.

Type
Research Article
Information
Journal of Hygiene , Volume 37 , Issue 2 , April 1937 , pp. 261 - 270
Copyright
Copyright © Cambridge University Press 1937

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