Hostname: page-component-76fb5796d-vvkck Total loading time: 0 Render date: 2024-04-25T14:19:35.811Z Has data issue: false hasContentIssue false
  • English
  • Français

The use of survival time in the analysis of neutralization tests for serum antibody surveys

Published online by Cambridge University Press:  15 May 2009

C. E. Gordon Smith  and
D. R. Westgarth
C. E. Gordon Smith
Affiliation:
Virus Research Officer, Institute for Medical Research Kuala Lumpur, MY
D. R. Westgarth
Affiliation:
Senior Statistician, Rubber Research Institute, Kuala Lumpur, MY
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

An analytical method based on survival-time response is described for use in survey neutralization tests with the neurotropic viruses in mice. The method is simple and has been shown to give consistent and comparable results, which enable tests which have been carried out with different doses of virus to be compared.

Type
Research Article
Information
Journal of Hygiene , Volume 55 , Issue 2 , June 1957 , pp. 224 - 238
Copyright
Copyright © Cambridge University Press 1957

References

REFERENCES

Box, G. E. P. & Cullumbine, H. (1947). Relationships between survival time and dosage with certain toxic agents. Brit. J. Pharmacol. 2, 27.Google ScholarPubMed
Brownlee, K. A. & Hamre, D. (1951). Studies on chemotherapy of vaccinia virus. I. An experimental design for testing antiviral agents. J. Bact. 61, 127.CrossRefGoogle ScholarPubMed
Bugher, J. C. (1948). Chapter on Yellow Fever in Diagnostic Procedures for Virus and Rickettsial Diseases, 1st ed. p. 267. New York: American Public Health Association.Google Scholar
Crocker, T. T. & Bennett, B. M. (1955). The slope assay for measurement of the lethal potency of meningopneumonitis virus in the chick embryo. J. Immunol. 75, 239.CrossRefGoogle ScholarPubMed
Finney, D. J. (1952). Statistical Method in Biological Assay. London: Chas. Griffin and Co.Google Scholar
Gard, S. (1940). Encephalomyelitis of mice. II. A method for the measurement of virus activity. J. exp. Med. 72, 69.CrossRefGoogle Scholar
Ipsen, J. & Toft, H.-I. (1946). Biological assay of strychnine in young mice using death-time and convulsion-time as biometrical scores. Acta pharm. tox., Kbh., 2, 167.CrossRefGoogle ScholarPubMed
Miller, L. C. & Tainter, M. L. (1944). Estimation of the ED50 and its error by means of logarithmic-probit graph paper. Proc. Soc. exp. Biol., N.Y., 57, 261.CrossRefGoogle Scholar
Perry, W. L. M. (1950). The design of toxicity tests. Spec. Rep. Ser. med. Res. Coun., Lond., no. 270.Google ScholarPubMed
Reed, L. J. & Muench, H. (1938). A simple method of estimating fifty per cent end points. Amer. J. Hyg. 27, 493.Google Scholar
Smithburn, K. C. (1954). Neutralizing antibodies against arthropod-borne viruses in the sera of long-time residents of Malaya and Borneo. Amer. J. Hyg. 59, 157.Google ScholarPubMed
Smithburn, K. C., Taylor, R. M., Rizk, F. & Kader, A. (1954 a). Immunity to certain arthropod-borne viruses among indigenous residents of Egypt. Amer. J. trop. Med. Hyg. 3, 9.CrossRefGoogle ScholarPubMed
Smithburn, K. C., Kerr, J. A. & Gatne, P. B. (1954 b). Neutralizing antibodies against certain viruses in the sera of residents of India. J. Immunol. 72, 248.CrossRefGoogle ScholarPubMed