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A randomized, controlled, double-blind, cross-over, clinical trial of Q fever vaccine in selected Queensland abattoirs

Published online by Cambridge University Press:  15 May 2009

R. A. Shapiro ,
V. Siskind ,
F. D. Schofield ,
N. Stallman ,
D. A. Worswick  and
B. P. Marmion
R. A. Shapiro*
Affiliation:
Department of Social and Preventive Medicine, University of Queensland
V. Siskind
Affiliation:
Department of Social and Preventive Medicine, University of Queensland
F. D. Schofield
Affiliation:
Department of Social and Preventive Medicine, University of Queensland
N. Stallman
Affiliation:
State Microbiological Laboratory, Queensland Department of Health
D. A. Worswick
Affiliation:
Division of Medical Virology, Institute of Medical and Veterinary Science, Adelaide, South Australia
B. P. Marmion
Affiliation:
Division of Medical Virology, Institute of Medical and Veterinary Science, Adelaide, South Australia
*
Dr R. A. Shapiro, Department of Social and Preventive Medicine, Medical School, University of Queensland, Herston Road, Herston, Qld, 4006.
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Summary

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A limited, randomized, blind, placebo-controlled trial of Q fever and influenza vaccines has been conducted in three Queensland abattoirs on a sequential analysis design. Ninety-eight subjects were given Q fever vaccine and 102 influenza vaccine. Q fever cases were observed in unvaccinated workers in all three abattoirs during the period of observation.

A total of seven Q fever cases in one group, one more than the number required to achieve statistical significance between the two vaccine groups, was reached after 15 months with the cases coming from two of the abattoirs. These Q fever cases were in the group which had been given influenza vaccine and none in that given Q fever vaccine.

Symptomless seroconversion rates of 24% were found in the remaining influenza virus vaccinees, and those without immunity were given Q fever vaccine.

Type
Research Article
Information
Epidemiology & Infection , Volume 104 , Issue 2 , April 1990 , pp. 267 - 273
Copyright
Copyright © Cambridge University Press 1990

References

REFERENCES

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