Hostname: page-component-7c8c6479df-94d59 Total loading time: 0 Render date: 2024-03-26T19:03:55.970Z Has data issue: false hasContentIssue false

Pertussis agglutinins in vaccinated children: better response with adjuvant

Published online by Cambridge University Press:  15 May 2009

N. W. Preston
Affiliation:
Department of Bacteriology and Virology, University of Manchester, Manchester M13 9PT
R. I. Mackay
Affiliation:
Hope Hospital, Salford, Lancs. M6 8HD
F. N. Bamford
Affiliation:
Department of Child Health (University of Manchester)St Mary's Hospital, Manchester M13 0JH
J. E. Crofts
Affiliation:
Vaccine Production Unit, Evans Biologicals Ltd, Speke, Liverpool L24 9JD
W. L. Burland
Affiliation:
Glaxo Laboratories, Greenford, Middlesex
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Children were immunized with a single batch of pertussis vaccine, either adsorbed on aluminium hydroxide or plain. With a primary course of three injections, adsorbed vaccine produced higher titres of pertussis agglutinins in the serum than did plain vaccine. There was no obvious difference in response between those who received the three doses at intervals of 1–2 months, starting at 3–4 months of age, and those in whom the third dose was delayed until about 6 months after the second, but the number of children in each group was small.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1974

References

REFERENCES

Abbott, J. D., Preston, N. W. & Mackay, R. I. (1971). Agglutinin response to pertussis vaccination in the child. British Medical Journal i, 86–8.Google Scholar
Butler, N. R., Voyce, M. A., Burland, W. L. & Hilton, M. L. (1969). Advantages of aluminium hydroxide adsorbed combined diphtheria, tetanus, and pertussis vaccines for the immunization of infants. British Medical Journal i, 663–6.Google Scholar
Central Health Services Council (1968). Immunization against Infectious Disease. London: Department of Health and Social Security.Google Scholar
Feldman, G. V. (1957). Pertussis antibody response after triple antigen. Archives of Disease in Childhood 32, 111–13.Google Scholar
Preston, N. W. (1966). Potency tests for pertussis vaccines: doubtful value of intracerebral challenge test in mice. Journal of Pathology and Bacteriology 91, 173–9.CrossRefGoogle ScholarPubMed
Preston, N. W. (1970). Technical problems in the laboratory diagnosis and prevention of whooping-cough. Laboratory Practice 19, 482–6.Google Scholar