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Molecular epidemiology of Mycobacterium avium complex isolated from patients with and without AIDS in Brazil and England

Published online by Cambridge University Press:  01 June 1999

M. A. S. TELLES ,
M. D. YATES ,
M. CURCIO ,
S. Y. M. UEKI ,
M. PALACI ,
D. J. HADAD ,
F. A. DROBNIEWSKI  and
A. L. POZNIAK
M. A. S. TELLES
Affiliation:
Seçao Micobacterias, Instituto Adolfo Lutz, São Paulo, Brazil
M. D. YATES
Affiliation:
PHLS Mycobacterium Reference Unit, Public Health Laboratory, Dulwich Hospital, East Dulwich Grove, London
M. CURCIO
Affiliation:
Seçao Micobacterias, Instituto Adolfo Lutz, São Paulo, Brazil
S. Y. M. UEKI
Affiliation:
Seçao Micobacterias, Instituto Adolfo Lutz, São Paulo, Brazil
M. PALACI
Affiliation:
Seçao Micobacterias, Instituto Adolfo Lutz, São Paulo, Brazil
D. J. HADAD
Affiliation:
Centro de Referencia e Treinamento em DST/AIDS, São Paulo, Brazil
F. A. DROBNIEWSKI
Affiliation:
PHLS Mycobacterium Reference Unit, Public Health Laboratory, Dulwich Hospital, East Dulwich Grove, London
A. L. POZNIAK
Affiliation:
Academic Department of Genitourinary Medicine, Department of Medicine, King's College School of Medicine, London, UK
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Abstract

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Mycobacterium avium complex (MAC) is ubiquitous throughout the world. It is an opportunistic pathogen in AIDS patients but the number of cases in HIV negative patients is also increasing. The aim of this study was to determine whether patients were being infected with different MAC strains or whether one strain was dominant. DNA obtained from isolates in Brazil and England were compared using pulsed field gel electrophoresis (PFGE). Strains from 22 Brazilian patients clustered into 7 groups but 68/90 patients had a unique strain. In all patients, Brazilian and English, the same strain was isolated repeatedly over time, some over several years. This study shows that it is most likely that Man is infected from the environment and that one strain can survive without change for many years both in the environment and in Man.

Type
Research Article
Information
Epidemiology & Infection , Volume 122 , Issue 3 , June 1999 , pp. 435 - 440
Copyright
© 1999 Cambridge University Press