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Laboratory studies on a strain of Asian influenza virus used as a living vaccine. (A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines*)

Published online by Cambridge University Press:  15 May 2009

D. Hobson ,
E. A. Gould  and
Hilary I. Flockton
D. Hobson
Affiliation:
The Department of Bacteriology, University of Liverpool
E. A. Gould
Affiliation:
The Department of Bacteriology, University of Liverpool
Hilary I. Flockton
Affiliation:
The Department of Bacteriology, University of Liverpool
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Two pools of living influenza vaccine derived from the Russian A 2 strain Iksha had given discrepant results in clinical trials. The less effective pool showed an increased thermostability of haemagglutinin, an increased elution rate from red blood cells and a reduced ability to grow in chorioallantoic membranes at temperatures above 40° C. The relationship of these findings to the virulence of influenza viruses is discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 65 , Issue 2 , June 1967 , pp. 255 - 262
Copyright
Copyright © Cambridge University Press 1967

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