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The importance of antineuraminidase antibodies in resistance to influenza A and immunologic memory for their synthesis

Published online by Cambridge University Press:  19 October 2009

A. N. Naikhin ,
I. M. Tsaritsina ,
E. V. Oleinikova ,
L. G. Syrodoeva ,
N. L. Korchanova ,
G. M. Denisov  and
Ya.S. Shvartsman
A. N. Naikhin
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
I. M. Tsaritsina
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
E. V. Oleinikova
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
L. G. Syrodoeva
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
N. L. Korchanova
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
G. M. Denisov
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
Ya.S. Shvartsman
Affiliation:
All-Union Research Institute of Influenza, Ministry of Health, USSR, Popova str. 15/17, Leningrad 197022
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Eight hundred and seventy-seven sera from 360 adults aged 18–50 who were under permanent observation from October 1980 to March 1981 have been studied by haemagglutination-inhibition (HI) and erythrocyte elution-inhibition (EI) tests – a simplified method of antineuraminidase antibody titration. It was demonstrated in some subjects infected with influenza A H1N1 and H3N2 viruses that the antibody rise was to one of the surface antigens only – haemagglutinin or neuraminidase. These subjects made up 5·2–25·8% of all examinees. The protective effect of antibodies to neuraminidase was similar to that of antihaemagglutinins. Interaction of both types of antibodies was observed in protection against the disease. Data have been obtained on the influence of antineuraminidase antibodies in decreasing the severity of natural infection with influenza A.

A study of heterologous immunologic responses to haemagglutinin and neuraminidase among persons immunized with live influenza A H1N1 and H3N2 vaccines and among children naturally infected with influenza A H3N2 demonstrated the presence of immunologic memory for antineuraminidase antibody synthesis. Thus, the suggestion of a common antigenic structure for neuraminidase Nl and N2 is made.

Type
Research Article
Information
Journal of Hygiene , Volume 91 , Issue 1 , August 1983 , pp. 131 - 138
Copyright
Copyright © Cambridge University Press 1983

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